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Title: Oral candidiasis as a clinical marker of highly active antiretroviral treatment failure in HIV-infected patients [La candidiasis bucal como marcador cl�nico de falla a la terapia antirretroviral altamente efectiva en pacientes infectados con VIH/sida]
Author: Lopez-Verdin, S.
Torrecilla-Ramirez, A.
Horta-Sandoval, A.C.
Andrade-Villanueva, J.F.
Bologna-Molina, R.
Issue Date: 2014
Abstract: Introduction Oral candidiasis is an opportunistic infection that is readily detectable in the clinic. It has been used to assess the immune status of HIV patients as well as the effectiveness of highly active antiretroviral therapy. Objective To determine the frequency of oral candidiasis infection among various indicators associated with antiretroviral therapy effectiveness. Material and methods Cross-sectional and analytical study, in which groups were initially created based on the use or not of antiretroviral therapy. Participants were subjected to questions on factors related to Candida infection, salivary flow measurements and a clinical examination of the oral cavity to determine the frequency of candidiasis Results The difference in the frequency of oral candidiasis between groups with and without antiretroviral therapy was significant (OR 2.6 IC95% 1.5-4.4). There were also a significant association with decreased number of CD4 lymphocytes. Discussion Resistance to anti-retroviral therapy constitutes one of the fundamental barriers to a successful treatment in patients infected with the human immunodeficiency virus, as do toxicities and adherence problems. Clinical markers such oral candidiasis is an easily and accesible parameter for the early detection of treatment failure. � 2013 ACIN. Published by Elsevier Espa�a, S.L. All rights reserved.
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