Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/43211
Title: Facial Nerve Regeneration through Progesterone-Loaded Chitosan Prosthesis. A Preliminary Report
Author: Bernal, M.
Guerra, T.-M.
Jaadari, A.
Issue Date: 2010
Abstract: This paper pursues non-quadratic stabilization of continuous-time Takagi-Sugeno (TS) models through a local approach first proposed only for stability analysis. This solution overcomes the problem of dealing with time-derivatives of the membership functions (MFs) by reducing global stability goals to something less restrictive that leads to stabilization domains (local asymptotic conditions), which is usually the case for nonlinear models that cannot be globally stabilized. Moreover, the new conditions are expressed as linear matrix inequalities (LMIs) which are efficiently solved by convex optimization techniques. For illustration purposes some examples are developed that clearly point out the advantages of the new framework over already existing approaches. " 2010 IEEE.",,,,,,"10.1109/FUZZY.2010.5584700",,,"http://hdl.handle.net/20.500.12104/43211","http://www.scopus.com/inward/record.url?eid=2-s2.0-78549238208&partnerID=40&md5=70b23f6748a0b43d1e425b27cf704622",,,,,,,,"2010 IEEE World Congress on Computational Intelligence, WCCI 2010",,,,,,"Scopus",,,,,,"Fuzzy Lyapunov Function (FLF); Linear Matrix Inequality (LMI); Local Stabilization; Stability Domain; Takagi-Sugeno (TS) models",,,,,,"Non-quadratic stabilization of Takagi-Sugeno models: A local point of view",,"Conference Paper" "43211","123456789/35008",,"Chávez-Delgado, M.E., Departamento de Otorrinolaringologia, Hospital Regional General No. 110, Inst. Mexicano Seg. Social (IMSS), Guadalajara, Jalisco, Mexico, Ctro. Invest. y Asistencia en Tecn., A.C. (CIATEJ), Av. Normalistas 800 S.H. Colinas, CP 44270, Guadalajara, Jalisco, Mexico; Mora-Galindo, J., Ctro. Invest. Biomed. Occid. (CIBO), IMSS, Guadalajara, Jalisco, Mexico; Gómez-Pinedo, U., Div. de Patol./Biotecnol. Ambiental, Ctro. de Invest. y Asistencia Tecn., A.C. (CIATEJ), Guadalajara, Jalisco, Mexico; Feria-Velasco, A., U. de Morfologia de Alta Resolucion, Ctr. Univ. de Cie. Biol. y Agropec., Universidad de Guadalajara, Zapopan, Jal, Mexico; Castro-Castañeda, S., Departamento de Cirugía, Hospital General de Zona No. 89, IMSS, Guadalajara, Jalisco, Mexico; López-Dellamary Toral, F.A., Inst. de Madera, Celulosa y Papel, Universidad de Guadalajara, Zapopan, Jalisco, Mexico; Luquin-De Anda, S., Ctr. Univ. de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; García-Segura, L.M., Instituto Cajal, Madrid, Spain; García-Estrada, J., Ctro. Invest. Biomed. Occid. (CIBO), IMSS, Guadalajara, Jalisco, Mexico",,"Chavez-Delgado, M.E.
Mora-Galindo, J.
Gomez-Pinedo, U.
Feria-Velasco, A.
Castro-Castaneda, S.
Lopez-Dellamary Toral, F.A.
Luquin-De Anda, S.
García-Segura, L.M.
García-Estrada, J.",,"2003",,"Biodegradable nerve guides have represented new treatment alternatives for nerve repairing. They are gradually biodegradable, exert biological effects directly to the injured nerve, and act as drug- or cell-delivery devices. Furthermore, progesterone (PROG) has been demonstrated to promote injured peripheral nerve regeneration. In this study, it was hypothesized that PROG delivered from chitosan prostheses provides better facial nerve regenerative response than chitosan prostheses with no PROG. As there are no reports on the use of the former as nerve-guide material in the regeneration of injured nerves, this is the main objective of the present work. Chitosan prostheses containing PROG were used to bridge 10-mm gaps in rabbit facial nerves. The regenerated nerves were evaluated 45 days after implantation in animals with the use of light microscopy and morphometric analysis. Gas chromatography was used in order to quantify PROG content in prosthesis prior to and after implantation in subcutaneous tissue at different periods of up to 60 days. In addition, the prosthesis walls were evaluated with histological techniques in order to assess their integrity and the surrounding tissue reaction. Chitosan prostheses allowed PROG release during the time needed for nerve regeneration. At 45 days myelinated nerve fibers were observed in both the proximal and distal stumps. This parameter and the N ratio were higher in the progesterone-treated group when compared to that of the vehicle control. Findings indicate that chitosan prostheses were useful in nerve regeneration, acting as a long-lasting PROG delivery device a faster nerve regeneration. " 2003 Wiley Periodicals, Inc.
URI: http://hdl.handle.net/20.500.12104/41432
http://www.scopus.com/inward/record.url?eid=2-s2.0-18244420936&partnerID=40&md5=f1ab3f8a7d04fe8965a02f15eaeaa309
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