Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/43096
Title: DEFB1 5'UTR polymorphisms modulate the risk of HIV-1 infection in mexican women
Author: Tajes, M.
Gutierrez-Cuesta, J.
Folch, J.
Ortuno-Sahagun, D.
Verdaguer, E.
Jimenez, A.
Junyent, F.
Lau, A.
Camins, A.
Pallas, M.
Issue Date: 2010
Abstract: Dietary interventions have been proposed as a way to increase lifespan and improve health. The senescence-accelerated prone 8 (SAMP8) mice have a shorter lifespan and show alterations in the central nervous system. Moreover, this mouse strain shows decreased sirtuin 1 protein expression and elevated expression of the acetylated targets NF?B and FoxO1, which are implicated in transcriptional control of key genes in cell proliferation and cell survival, in reference to control strain, SAMR1. After eight weeks of intermittent fasting, sirtuin 1 protein expression was recovered in SAMP8. This recovery was accompanied by a reduction in the two acetylated targets. Furthermore, SAMP8 showed a lower protein expression of BDNF and HSP70 while intermittent fasting re-established normal values. The activation of JNK and FoxO1 was also reduced in SAMP8 mice subjected to an IF regimen, compared with control SAMP8. Our findings provide new insights into the participation of sirtuin 1 in ageing and point to a potential novel application of this enzyme to prevent frailty due to ageing processes in the brain. " 2010 Elsevier Inc.",,,,,,"10.1016/j.exger.2010.04.010",,,"http://hdl.handle.net/20.500.12104/43096","http://www.scopus.com/inward/record.url?eid=2-s2.0-77955852679&partnerID=40&md5=a87562a74312bbf96a17093cd10c0f6a",,,,,,"9",,"Experimental Gerontology",,"702
710",,"45",,"Scopus
WOS",,,,,,"ADAM10; Ageing; BDNF; Neurodegeneration; NF?B; Sirtuin 1",,,,,,"Neuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8)",,"Article" "42276","123456789/35008",,"Estrada-Aguirre, J.A., Maestría en Ciencias Biomédicas, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico; Osuna-Ramírez, I., Maestría en Ciencias Biomédicas, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico; Prado Montes de Oca, E., In Silico Laboratory, Biosafety Area, Medical and Pharmaceutical Biotechnology Unit, Research Center in Technology and Design Assistance of Jalisco State, National Council of Science and Technology (CIATEJ AC, CONACYT), Guadalajara, Jalisco, Mexico, Molecular Biology Laboratory, Biosafety Area, Medical and Pharmaceutical Biotechnology Unit, Research Center in Technology and Design Assistance of Jalisco State, National Council of Science and Technology (CIATEJ AC, CONACYT), Guadalajara, Jalisco, Mexico; Ochoa-Ramírez, L.A., Centro de Medicina Genómica del Hospital General de Culiacán Dr. Bernardo J. Gastelum, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, Mexico; Ramírez, M., Laboratorio de Histocompatibilidad, Hospital General de Culiacán Dr. Bernardo J. Gastélum, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, Mexico; Magallán-Zazueta, L.G., Instituto Sinaloense de las Mujeres, Culiacán Sinaloa, Mexico; González-Beltrán, M.S., Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico; Cázarez-Salazar, S.G., Maestría en Ciencias Biomédicas, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico, Centro de Medicina Genómica del Hospital General de Culiacán Dr. Bernardo J. Gastelum, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, Mexico; Rangel-Villalobos, H., Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán, Jalisco, Mexico; Velarde-Félix, J.S., Maestría en Ciencias Biomédicas, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico, Centro de Medicina Genómica del Hospital General de Culiacán Dr. Bernardo J. Gastelum, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, Mexico, Unidad Académica Escuela de Biología, Cuerpo Académico Inmunogenética y Evolución UAS-CA-265, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico",,"Estrada-Aguirre, J.A.
Osuna-Ramirez, I.
Prado Montes de Oca, E.
Ochoa-Ramirez, L.A.
Ramirez, M.
Magallon-Zazueta, L.G.
Gonzalez-Beltran, M.S.
Cazarez-Salazar, S.G.
Rangel-Villalobos, H.
Velarde-Felix, J.S.",,"2014",,"Immunologic and genetic factors are involved in HIV-1/AIDS pathogenesis. Defensins are key molecules in innate immunity that participate in the control and/or development of infection and disease. Using PCR-RFLPs, we determined the association between HIV-1/AIDS and human ?-defensin 1 (DEFB1) 5'UTR -52 G/A (rs1799946), -44 C/G (rs1800972), and -20 G/A (rs11362) polymorphisms in three groups of women from the state of Sinaloa, located in the Northwest region of Mexico: i) healthy blood donors; ii) sex-workers; and iii) HIV-1 patients. The -52GG genotype was more frequent in blood donors than in patients (p= 0.023; Odds Ratio, OR= 0.49; 95% CI= 0.25-0.95), whereas the -52GA genotype was significantly higher in patients (p= 0.013; OR= 2.03; 95% CI= 1.11-3.79, statistical power SP= 98.8%), as well as the frequencies of -20A allele (p= 0.017; OR= 1.60; 95% CI= 1.06-2.40), -20AA genotype (p= 0.047; OR = 2.02; 95% CI= 0.93-4.33) and the ACA haplotype with respect to healthy blood donors (p= 0.000012; OR= 5.82; 95% CI= 2.33-16.43, SP= 99.89%) and sex-workers (p= 0.019; OR= 2.18; 95% CI= 1.07-4.46). Conversely, the ACG haplotype was higher in healthy blood donors than in patients (p= 0.009; OR= 0.55; 95% CI= 0.34-0.89). In addition, the -44CC genotype was associated with a low plasma viral load (p= 0.015), whereas AGA, AGG and GGA haplotypes were more prevalent in individuals with high CD4 counts (p= 0.004, 0.046, and 0.029, respectively). These findings associate DEFB1 5'UTR polymorphisms with HIV-1/AIDS in Mexican women for the first time. " 2014 Bentham Science Publishers.
URI: http://hdl.handle.net/20.500.12104/40497
http://www.scopus.com/inward/record.url?eid=2-s2.0-84906245095&partnerID=40&md5=7bc11326f11e07820a03839833215365
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