Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42909
Title: Molecular basis and current treatment for alcoholic liver disease
Author: Marquez-Aguirre, A.L.
Canales-Aguirre, A.A.
Gomez-Pinedo, U.
Galvez-Gastelum, F.J.
Issue Date: 2010
Abstract: Introduction: Liver fibrosis and its end stage, cirrhosis, is an enormous worldwide health problem. Hepatic encephalopathy (HE) or portal-systemic encephalopathy continues to be a majorclinical problem of long-term cirrhosis. In this review we emphasise the molecular basis of HE and the involvement of oxidative stress in the development of this disease. Background: Several studies suggest that the pathogenesis of HE could be multifactorial and have implicated different factors, such as alterations in blood brain barrier, substances; such as ammonia and manganese, neurotransmission disorders such as dopamine, glutamate and GABA. Development: HE is a severe complication of both acute and chronic liver failure. Neuropathologically, it is characterized by astrocyte changes known as Alzheimer type II astrocytosis. In addition, astrocytes manifest altered expression of astrocyte-specific proteins, such as, glial fibrillary acidic protein, glutamine synthetase, monoamine oxidase and peripheral type benzodiazepine receptors. Conclusions: HE is a complex neuropsychiatric syndrome associated with liver failure. These alterations are products of increases in oxidative stress in brain due to neurotoxin activity. The main strategy for HE treatment is directed at ammonia reduction, which can be achieved either by decreasing its absorption/production or increasing its removal. " 2009 Sociedad Española de Neurología.",,,,,,"10.1016/j.nrl.2009.12.001",,,"http://hdl.handle.net/20.500.12104/42909","http://www.scopus.com/inward/record.url?eid=2-s2.0-77956643845&partnerID=40&md5=db26d7da0b002a266ef884097bc8c9bc",,,,,,"4",,"Neurologia",,"239
247",,"25",,"Scopus
WOS",,,,,,"Ammonia; Hepatic encephalopathy; Manganese; Neurotoxins; Oxidative stress",,,,,,"Molecular aspects of hepatic encephalopathy [Aspectos moleculares de la encefalopatía hepética]",,"Article" "40861","123456789/35008",,,,"Bentos-Pereira,Alba",,"2003",,,,,,,,"10.1021/es0222465",,"1082-6467","http://hdl.handle.net/20.500.12104/39082","http://dx.doi.org/10.1665/1082-6467(2003)012[0149:MNGOEP]2.0.CO;2",,,,"Orthopterists' Society",,"2",,"Journal of Orthoptera Research",,"149
157",,"12",,"BioOne",,,,,,,,,,,,"Mariascopia n. gen. (Orthoptera, Eumastacoidea, Proscopiidae)",,"Journal Article" "40867","123456789/35008",,"Armendáriz-Borunda, J., Institute for Molecular Biology in Medicine and Gene Therapy, Guadalajara, Jalisco, Mexico, OPD Civil Hospital of Guadalajara, Guadalajara, Jalisco, Mexico, Institute for Molecular Biology in Medicine and Gene Therapy, Apdo Postal 2-123, Guadalajara, Jalisco 44281, Mexico; Islas-Carbajal, M.C., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Jalisco, Mexico; Meza-García, E., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Jalisco, Mexico; Rincón, A.R., Institute of Chronic Degenerative Diseases, Guadalajara, Jalisco, Mexico; Lucano, S., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Jalisco, Mexico; Sandoval, A.S., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Jalisco, Mexico; Salazar, A., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Jalisco, Mexico; Berumen, J., Unit of Genomic Medicine, General Hospital of México, México, Mexico; Alvarez, A., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Jalisco, Mexico; Alvarez, A., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Jalisco, Mexico; Covarrubias, A., OPD Civil Hospital of Guadalajara, Guadalajara, Jalisco, Mexico; Aréchiga, G., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Jalisco, Mexico; García, L., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Guadalajara, Jalisco, Mexico",,"Armendariz-Borunda, J.
Islas-Carbajal, M.C.
Meza-García, E.
Rincon, A.R.
Lucano, S.
Sandoval, A.S.
Salazar, A.
Berumen, J.
Alvarez, A.
Alvarez, A.
Covarrubias, A.
Arechiga, G.
García, L.",,"2006",,"[No abstract available]",,,,,,"10.1136/gut.2006.107136",,,"http://hdl.handle.net/20.500.12104/39088","http://www.scopus.com/inward/record.url?eid=2-s2.0-33750288398&partnerID=40&md5=41c7b74fbf15cc106cd0f409ec6f7c43",,,,,,"11",,"Gut",,"1663
1665",,"55",,"Scopus
WOS",,,,,,,,,,,,"A pilot study in patients with established advanced liver fibrosis using pirfenidone [4]",,"Letter" "44689","123456789/35008",,"Miranda-Mendez, A., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Jalisco 44281, Mexico; Lugo-Baruqui, A., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Jalisco 44281, Mexico, OPD Hospital Civil de Guadalajara, Jalisco 44340, Mexico; Armendariz-Borunda, J., Institute for Molecular Biology in Medicine and Gene Therapy, University of Guadalajara, Jalisco 44281, Mexico, OPD Hospital Civil de Guadalajara, Jalisco 44340, Mexico",,"Miranda-Mendez, A.
Lugo-Baruqui, A.
Armendariz-Borunda, J.",,"2010",,"Alcohol use disorders and alcohol dependency affect millions of individuals worldwide. The impact of these facts lies in the elevated social and economic costs. Alcoholic liver disease is caused by acute and chronic exposure to ethanol which promotes oxidative stress and inflammatory response. Chronic consumption of ethanol implies liver steatosis, which is the first morphological change in the liver, followed by liver fibrosis and cirrhosis. This review comprises a broad approach of alcohol use disorders, and a more specific assessment of the pathophysiologic molecular basis, and genetics, as well as clinical presentation and current modalities of treatment for alcoholic liver disease. " 2010 by the authors.
URI: http://hdl.handle.net/20.500.12104/42910
http://www.scopus.com/inward/record.url?eid=2-s2.0-77954791557&partnerID=40&md5=d1bdd72610457ba72bbbced8ac196d81
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=20622998
Appears in Collections:Producción científica UdeG

Files in This Item:
There are no files associated with this item.


Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.