Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42905
Title: Modulation of PPAR-? by nutraceutics as complementary treatment for obesity-related disorders and inflammatory diseases
Author: Ortuno Sahagun, D.
Marquez-Aguirre, A.L.
Quintero-Fabian, S.
Lopez-Roa, R.I.
Rojas-Mayorquin, A.E.
Issue Date: 2012
Abstract: A direct correlation between adequate nutrition and health is a universally accepted truth. The Western lifestyle, with a high intake of simple sugars, saturated fat, and physical inactivity, promotes pathologic conditions. The main adverse consequences range from cardiovascular disease, type 2 diabetes, and metabolic syndrome to several cancers. Dietary components influence tissue homeostasis in multiple ways and many different functional foods have been associated with various health benefits when consumed. Natural products are an important and promising source for drug discovery. Many anti-inflammatory natural products activate peroxisome proliferator-activated receptors (PPAR); therefore, compounds that activate or modulate PPAR-gamma (PPAR-?) may help to fight all of these pathological conditions. Consequently, the discovery and optimization of novel PPAR-? agonists and modulators that would display reduced side effects is of great interest. In this paper, we present some of the main naturally derived products studied that exert an influence on metabolism through the activation or modulation of PPAR-?, and we also present PPAR-?-related diseases that can be complementarily treated with nutraceutics from functional foods. � 2012 D. Ortu�o Sahag�n et al.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-84871847564&partnerID=40&md5=81613e31b37e5f2bb0303b4cbae44677
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=23251142
http://hdl.handle.net/20.500.12104/42905
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