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Title: Methylenetetrahydrofolate reductase C677T polymorphism and Factor V Leiden variant in Mexican women with preeclampsia/eclampsia
Author: Davalos, I.P.
Moran, M.C.
Martinez-Abundis, E.
Gonzalez-Ortiz, M.
Flores-Martinez, S.E.
Machorro, V.
Sandoval, L.
Figuera, L.E.
Mena, J.P.
Oliva, J.M.
Tlacuilo-Parra, J.A.
Sanchez-Corona, J.
Salazar-Paramo, M.
Issue Date: 2005
Abstract: The etiology of preeclampsia is still a matter of controversy. An association between hyperhomocysteinemia and preeclamptic patients has been described. A common missense mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased plasma homocysteine concentrations. In addition, the polymorphism of gene encoding for Factor V Leiden G1691A is associated with a prothrombotic state in heterozygous subjects. Both mutations in these thrombophilic proteins appear to have different prevalence in the general population and in patients with preeclampsia/eclampsia (PE/E). We studied single nucleotide polymorphisms for MTHFR C677T and coagulation Factor V Leiden in 33 Mexican patients with PE/E as a genetic risk factor for these diseases, comparing with a normotensive pregnant control group. The genotype and allele frequencies of MTHFR C677T and Factor V Leiden mutations between Mexican women with PE/E and healthy controls were not different. We conclude that these polymorphisms do not contribute in the etiology of PE/E as it has been reported in other populations. � 2005 Elsevier Inc. All rights reserved.
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