Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42572
Title: Liver function test results predict nutritional status evaluated by arm anthropometric indicators
Author: Del Pilar Alatorre-Carranza, M.
Miranda-Diaz, A.
Yanez-Sanchez, I.
Pizano-Martinez, O.
Hermosillo-Sandoval, J.M.
Vazquez-Del Mercado, M.
Hernandez-Hoyos, S.
Martinez-Abundis, R.
Fafutis-Morris, M.
Segura-Ortega, J.
Delgado-Rizo, V.
Issue Date: 2009
Abstract: Background: Liver fibrosis is the result of continuous liver injury stemming from different etiological factors. Bile duct injury induces an altered expression of TGF-?, which has an important role in liver fibrosis because this cytokine induces the expression of target genes such as collagens, PAI-1, TIMPs, and others that lead to extracellular matrix deposition. Smad7 is the principal inhibitor that regulates the target gene transcription of the TGF-? signaling. The aim of the study was to determine whether Smad7 mRNA expression correlates with the gene expression of TGF-?, Col I, Col III, Col IV, or PAI-1 in liver fibrosis secondary to bile duct injury (BDI). Results: Serum TGF-? concentration was higher in BDI patients (39 296 pg/ml) than in liver donors (9008 pg/ml). Morphometric analysis of liver sections showed 41.85% of tissue contained fibrotic deposits in BDI patients. mRNA expression of Smad7, Col I, and PAI-1 was also significantly higher (P < 0.05) in patients with BDI than in controls. Smad7 mRNA expression correlated significantly with TGF-? concentration, Col I and Col III expression, and the amount of fibrosis. Conclusion: We found augmented serum concentration of TGF-? and an increase in the percentage of fibrotic tissue in the liver of BDI patients. Contrary to expected results, the 6-fold increase in Smad7 expression did not inhibit the expression of TGF-?, collagens, and PAI-1. We also observed greater expression of Col I and Col III mRNA in BDI patients and significant correlations between their expression and TGF-? concentration and Smad7 mRNA expression. " 2009 del Pilar Alatorre-Carranza et al; licensee BioMed Central Ltd.",,,,,,"10.1186/1471-230X-9-81",,,"http://hdl.handle.net/20.500.12104/42572","http://www.scopus.com/inward/record.url?eid=2-s2.0-71049171279&partnerID=40&md5=fbf9df38be5db45bce560978ca83e178
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=19878580",,,,,,,,"BMC Gastroenterology",,"81",,"9",,"Scopus
MEDLINE",,,,"Index Medicus;Adolescent;Adult;Aged;Biopsy;Cholestasis/co [Complications];Cholestasis/ge [Genetics];Cholestasis/me [Metabolism];Disease Progression;Enzyme-Linked Immunosorbent Assay;Extracellular Matrix Proteins/bi [Biosynthesis];Extracellular Matrix Proteins/ge [Genetics];Female;Gene Expression;Humans;Liver/pa [Pathology];Liver Cirrhosis/et [Etiology];Liver Cirrhosis/ge [Genetics];Liver Cirrhosis/me [Metabolism];Male;Middle Aged;RNA, Messenger/bi [Biosynthesis];RNA, Messenger/ge [Genetics];Reverse Transcriptase Polymerase Chain Reaction;Smad7 Protein/bi [Biosynthesis];Smad7 Protein/ge [Genetics];Transforming Growth Factor beta/bi [Biosynthesis];Transforming Growth Factor beta/ge [Genetics];Young Adult",,,,,,,,"Liver fibrosis secondary to bile duct injury: Correlation of Smad7 with TGF-? and extracellular matrix proteins",,"Article" "38304","123456789/35008",,,,"Rodríguez Lapuente, Manuel",,"1987",,,,,,,,,,"0186-0348","http://hdl.handle.net/20.500.12104/36525",,,"Español",,,,"7",,"Secuencia",,"48-56",,,,"CLASE",,,,,,,,"Historia social",,,,"Las razones del Dr. Mora para la separación de la iglesia y el Estado",,"journalArticle" "44352","123456789/35008",,"Hurtado-López, E.F., Unidad de Investigación en Epidemiología Clínica, Guadalajara, Jalisco, Mexico, Servicio de Gastroenterología Y Nutrición, UMAE Hospital de Pediatría, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico, Instituto de Nutrición Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Larrosa-Haro, A., Unidad de Investigación en Epidemiología Clínica, Guadalajara, Jalisco, Mexico, Servicio de Gastroenterología Y Nutrición, UMAE Hospital de Pediatría, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico, Instituto de Nutrición Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Servicio de Gastroenterología Y Nutrición, Unidad Médica de Alta Especialidad, Instituto Mexicano del Seguro Social, Belisario Domínguez 735, Sector Libertad, Guadalajara Jalisco, CP 44240, Mexico; Vásquez-Garibay, E.M., Instituto de Nutrición Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Macías-Rosales, R., Unidad de Investigación en Epidemiología Clínica, Guadalajara, Jalisco, Mexico, Servicio de Gastroenterología Y Nutrición, UMAE Hospital de Pediatría, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Troyo-Sanromán, R., Instituto de Nutrición Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Bojórquez-Ramos, M.C., Servicio de Gastroenterología Y Nutrición, UMAE Hospital de Pediatría, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico",,"Hurtado-Lopez, E.F.
Larrosa-Haro, A.
Vasquez-Garibay, E.M.
MacIas-Rosales, R.
Troyo-Sanroman, R.
Bojorquez-Ramos, M.C.",,"2007",,"OBJECTIVES: To compare the anthropometric indicators based on weight and height with the anthropometric indicators based on arm measurements and to predict the anthropometric nutritional status with liver function tests (LFTs) in children with chronic liver disease (CLD). PATIENTS AND METHODS: A cross-sectional study in a referral pediatric hospital enrolled 79 children with CLD (mean age 72.6 +/- 61.8 months, 54% female). An independent variable of LFT was used to determine the outcome variable of nutritional status. Anthropometric indicators of height versus age, weight versus height, head circumference versus age, and arm indicators versus age were analyzed with Pearson correlation, the determination coefficient r, and multiple regression. RESULTS: A total of 44.3% of patients studied had growth impairment. The anthropomorphic indicator of weight for height identified malnutrition in 11.4%, compared with 43% identified by mid- to upper arm circumference (MUAC) and 40.5% identified with total arm area. MUAC (P < 0.001), total arm circumference (P < 0.001), arm muscle area (P = 0.009), and arm fat area (P = 0.023) identified more cases of z score less than -2 SD than weight/height. The presence of ascites misled weight-for-height measurements. Conjugated bilirubin and albumin had significant correlations with almost all of the anthropometric indicators. Alkaline phosphatase correlated significantly with all of the arm anthropometric indicators. A regression analysis led to 7 prediction models; the highest prediction of z score less than -2 SD was with triceps skinfold and conjugated bilirubin, albumin, and ?-glutamyltransferase; height-for-age z score less than -2 SD was predicted by measurements of conjugated bilirubin, prothrombin time, and alanine aminotransferase. CONCLUSIONS: The data presented underline the correlation between the liver damage severity evaluated by LFT and the nutritional status estimated by anthropometric indicators. In our view these observations reflect the close relationship between liver function and the degree of liver damage to growth and current nutritional status. " 2007 Lippincott Williams & Wilkins, Inc.
URI: http://hdl.handle.net/20.500.12104/42573
http://www.scopus.com/inward/record.url?eid=2-s2.0-37349056062&partnerID=40&md5=7337db5970f5e66929840f3fd13e9802
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