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Title: Induction of micronucleated erythrocytes in mouse peripheral blood after cutaneous application of 5-fluorouracil
Author: Zuniga-Gonzalez, G.M.
Torres-Bugarin, O.
Zamora-Perez, A.L.
Gomez-Meda, B.C.
Ramos-Ibarra Ma.L.
Gallegos-Arreola, P.
Flores-Garcia, A.
Lopez-Uribe, A.
Issue Date: 2003
Abstract: Background. For topically applied drugs such as 5-fluorouracil (5-FU), dosage is not as precise as for other drug administration pathways. Consequently, quantity of drug delivered may differ among individuals and applications. 5-FU is used in treatment of different diseases and has been reported as a clastogenic compound by micronucleus assay. Methods. To determine whether 5-FU cream (5% 5-FU) absorbed through skin can produce genotoxic or cytotoxic effect in mouse bone marrow, induction of micronucleated erythrocytes (MNE) in mouse peripheral blood was examined after cutaneous application of 5-FU daily for 5 days. Results. 5-FU cream induced significant micronuclei at doses of 37.5 mg (total weight of cream)/2 cm2 and 75.0 mg/2 cm2, as well as cytotoxic effects at doses of 150.0 and 300.0 mg/2 cm2. Conclusions. Cutaneous application of 5-FU increased number of MNE in mouse peripheral blood. These data emphasize the importance of using correct dose when applying drugs topically. 2003 IMSS. Published by Elsevier Science Inc.
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