Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/42106
Title: IL-12 and IL-18 levels in serum and gingival tissue in aggressive and chronic periodontitis
Author: Petri, M.H.
Satoh, M.
Martin-Marquez, B.T.
Vargas-Ramirez, R.
Jara, L.J.
Saavedra, M.A.
Cruz-Gonzalez, C.
Andrade-Ortega, L.
Vera-Lastra, O.
Salazar-Paramo, M.
Prieto-Parra, R.E.
Gonzalez-Lopez, L.
Gamez-Nava, J.I.
Ramirez-Sanchez, H.U.
Chan, J.Y.F.
Ross, S.J.
Chan, E.K.L.
Vazquez-Del Mercado, M.
Issue Date: 2013
Abstract: Introduction: Autoantibodies and clinical manifestations in polymyositis/dermatomyositis (PM/DM) are affected by both genetic and environmental factors. The high prevalence of DM and anti-Mi-2 in Central America is thought to be associated with the high UV index of the area. The prevalences of autoantibodies and the clinical manifestations of PM/DM were evaluated comparing two cohorts in Mexico. Methods: Ninety-five Mexican patients with PM/DM (66 DM, 29 PM; 67 Mexico City, 28 Guadalajara) were studied. Autoantibodies were characterized by immunoprecipitation using 35S-methionine labeled K562 cell extract. Clinical information was obtained from medical records. Results: DM represented 69% of PM/DM and anti-Mi-2 was the most common autoantibody (35%), followed by anti-p155/140 (11%); however, anti-Jo-1 was only 4%. The autoantibody profile in adult-onset DM in Mexico City versus Guadalajara showed striking differences: anti-Mi-2 was 59% versus 12% (P = 0.0012) whereas anti-p155/140 was 9% versus 35% (P = 0.02), respectively. A strong association of anti-Mi-2 with DM was confirmed and when clinical features of anti-Mi-2 (+) DM (n = 30) versus anti-Mi-2 (-) DM (n = 36) were compared, the shawl sign (86% versus 64%, P < 0.05) was more common in the anti-Mi-2 (+) group (P = 0.0001). Levels of creatine phosphokinase (CPK) were higher in those who were anti-Mi-2 (+) but they responded well to therapy. Conclusions: Anti-Mi-2 has a high prevalence in Mexican DM and is associated with the shawl sign and high CPK. The prevalence of anti-Mi-2 and anti-p155/140 was significantly different in Mexico City versus Guadalajara, which have a similar UV index. This suggests roles of factors other than UV in anti-Mi-2 antibody production. " 2013 Petri et al.; licensee BioMed Central Ltd.",,,,,,"10.1186/ar4207",,,"http://hdl.handle.net/20.500.12104/42106","http://www.scopus.com/inward/record.url?eid=2-s2.0-84875689792&partnerID=40&md5=774ec2092f47770afe26f28b277b559e",,,,,,"2",,"Arthritis Research and Therapy",,,,"15",,"Scopus
WOS",,,,,,,,,,,,"Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara",,"Article" "43835","123456789/35008",,"Sánchez-Hernández, P.E., Laboratorio de Inmunología, División de Disciplinas, Básicas, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Zamora-Perez, A.L., Departamento de Clínicas Odontológicas Integrales, División de Disciplinas Clinicas, Instituto de Investigacion en Odontología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Fuentes-Lerma, M., Departamento de Clínicas Odontológicas Integrales, División de Disciplinas Clinicas, Instituto de Investigacion en Odontología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Depto. de Clínicas, División de Biomédicas e Ingenierías, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, Mexico; Robles-Gómez, C., Departamento de Clínicas Odontológicas Integrales, División de Disciplinas Clinicas, Instituto de Investigacion en Odontología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Departamento de Clínicas Odontológicas Integrales, División de Disciplinas Clínicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Mariaud-Schmidt, R.P., Departamento de Clínicas Odontológicas Integrales, División de Disciplinas Clinicas, Instituto de Investigacion en Odontología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Guerrero-Velázquez, C., Departamento de Clínicas Odontológicas Integrales, División de Disciplinas Clinicas, Instituto de Investigacion en Odontología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico",,"Sanchez-Hernandez, P.E.
Zamora-Perez, A.L.
Fuentes-Lerma, M.
Robles-Gomez, C.
Mariaud-Schmidt, R.P.
Guerrero-Velazquez, C.",,"2011",,"Objective: The aim of this study was to compare the levels of interleukin-12 (IL-12) and IL-18 in gingival tissue and serum between patients with chronic (n=18) or aggressive periodontitis (n=12) and healthy subjects (HS) (n=9). Methods: Gingival tissue biopsies and serum were obtained from all study subjects. The tissue was homogenized and cytokines IL-12 and IL-18 were quantified by enzyme-linked immunosorbent assay. Results: Interleukin-12 levels in gingival tissue were significantly higher in aggressive periodontitis patients than in HS; serum IL-12 was significantly elevated in aggressive periodontitis relative to both chronic periodontitis (CP) and HS. IL-18 levels in gingival tissue showed no significant differences between the groups. Patients with CP showed significantly elevated levels of serum IL-18 compared with HS; however, the aggressive periodontitis group showed no significant differences with either the CP group or the HS. Conclusions: Our results showed higher levels of IL-12 in gingival tissue and serum of patients with aggressive periodontitis, and IL-18 was elevated in the serum of CP patients. The patterns of IL-12 and IL-18 are different in chronic and aggressive periodontitis; this finding suggests distinctive mechanisms of immunopathogenesis between these forms of periodontitis. " 2011 John Wiley & Sons A/S.
URI: http://hdl.handle.net/20.500.12104/42056
http://www.scopus.com/inward/record.url?eid=2-s2.0-79957970148&partnerID=40&md5=b26c193996fa53b58221a26c035d5d8b
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=21332601
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