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|Title:||Immunotoxicity and hepatic function evaluation in Nile tilapia (Oreochromis niloticus) exposed to diazinon|
|Abstract:||The mechanisms that regulate disease progression during hepatitis C virus (HCV) infection and the response to treatment are not clearly identified. Numerous studies have demonstrated that a strong host immune response against HCV favors HCV clearance. In addition, genetic factors and metabolic machinery, particularly cholesterol modulation, are involved in HCV infection. It is likely that the interplay between all of these factors contributes to the outcome of HCV infection. In recent years, the world has experienced its largest epidemic of obesity. Mexico and the United States are the leading sufferers from this epidemic at the global level. Obesity is associated with the development of WJG 20th Anniversary Special Issues (2): Hepatitis C virus TOPIC HIGHLIGHT numerous pathologies including hypercholesterolemia which is one of the eight most important risk factors for mortality in Mexico. This may be related to the course of HCV infection in this population. Here, we focus on the urgent need to study the progression of HCV infection in relation to ethnic characteristics. Discoveries are discussed that hold promise in identifying immune, metabolic and genetic factors that, in conjunction, could be therapeutic targets or predictors of the progression of HCV infection. " 2014 Baishideng Publishing Group Co., Limited. All rights reserved.",,,,,,"10.3748/wjg.v20.i13.3443",,,"http://hdl.handle.net/20.500.12104/42079","http://www.scopus.com/inward/record.url?eid=2-s2.0-84897539914&partnerID=40&md5=a9622a6af938393a3167e4a340957fc2|
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=24707127",,,,,,"13",,"World Journal of Gastroenterology",,"3443
MEDLINE",,,,"Index Medicus;Animals;Antiviral Agents/tu [Therapeutic Use];Disease Progression;Fatty Liver/im [Immunology];Hepacivirus;Hepatitis C/ge [Genetics];Hepatitis C/im [Immunology];Humans;Hypercholesterolemia/co [Complications];Hypercholesterolemia/vi [Virology];Immunity, Innate;Lipid Metabolism;Mexico;Obesity/co [Complications];Risk Factors;United States",,"Genetics; Hepatitis C virus; Immune response; Lipids; Metabolism",,,,,,"Immunologic, metabolic and genetic factors in hepatitis C virus infection",,"Article" "43868","123456789/35008",,"Girón-Pérez, M.I., University of Guadalajara, Cellular and Molecular Biology Department, Carretera a Nogales Km 15.5, Las Agujas, Zapopan, 45110 Jalisco, Mexico, Autonomous University of Nayarit, Cd la Cultura Amado Nervo Blvd, Tepic-Xalisco S/N, Tepic, Nayarit, Mexico; Santerre, A., University of Guadalajara, Cellular and Molecular Biology Department, Carretera a Nogales Km 15.5, Las Agujas, Zapopan, 45110 Jalisco, Mexico; Gonzalez-Jaime, F., Hospital ISSSTE Aquiles Calles Ramírez, Paseo de la Loma S/N, Tepic, Nayarit, Mexico; Casas-Solis, J., University of Guadalajara, Cellular and Molecular Biology Department, Carretera a Nogales Km 15.5, Las Agujas, Zapopan, 45110 Jalisco, Mexico; Hernández-Coronado, M., University of Guadalajara, Cellular and Molecular Biology Department, Carretera a Nogales Km 15.5, Las Agujas, Zapopan, 45110 Jalisco, Mexico; Peregrina-Sandoval, J., University of Guadalajara, Cellular and Molecular Biology Department, Carretera a Nogales Km 15.5, Las Agujas, Zapopan, 45110 Jalisco, Mexico; Takemura, A., University of the Ryukyus, Tropical Biosphere Research Center, Sesoko Station, 3422 Sesoko, Motobu, Okinawa, 905-0227, Japan; Zaitseva, G., University of Guadalajara, Cellular and Molecular Biology Department, Carretera a Nogales Km 15.5, Las Agujas, Zapopan, 45110 Jalisco, Mexico",,"Giron-Perez, M.I.
Zaitseva, G.",,"2007",,"The LC50 of the organophosphorus pesticides (OPs) diazinon to Nile tilapia (Oreochromis niloticus) was determined, thereafter, hepatic activity, phagocytic index, percentages of active cells, relative spleen weight, total IgM concentration and lymphoproliferation rates were compared between diazinon exposed groups (LC50 and 1/2LC50) and non-exposed control group. Experimental data show that diazinon is highly toxic for juvenile Nile tilapia (LC50 = 7.830 ppm) and presents immunotoxic properties which affect both the innate and cellular adaptive immune responses of this fish, as revealed by the fact that splenocyte proliferation and phagocytic indices were significantly decreased after acute exposure to the pesticide. However, the hepatic biochemical parameters and the total circulating IgM concentrations were not affected in this experimental model. " 2007 Elsevier Ltd. All rights reserved.
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