Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41962
Title: How independent are the appearances of n-mers in different genomes?
Author: Limon-Morales, O.
Soria-Fregozo, C.
Arteaga-Silva, M.
Hernandez Gonzalez, M.
Vazquez-Palacios, G.
Bonilla-Jaime, H.
Issue Date: 2014
Abstract: Male sexual behavior (MSB) in rodents, in both its consummatory and motivational components, is regulated by hormones such as testosterone, 17?-estradiol and 5-?-dihydrotestosterone. In experiments, neonatal treatment with clomipramine (CMI; a serotonin reuptake inhibitor) reproduces some of the signs of depression in adult age, including reduced sexual behavior manifested in a lower percentage of subjects that mount, intromit and ejaculate, although their testosterone levels were not altered. However, the effect of this treatment on estrogen levels and the consequences of hormone substitution using 17?-estradiol and 5-?-dihydrotestosterone on the expression of male sexual behavior are still unknown. Therefore, the objective of the present study was to analyze the effect of neonatal treatment with CMI on plasma testosterone and 17?-estradiol levels, and the role of testosterone, 17?-estradiol and 5-?-dihydrotestosterone in altering the consummatory and motivational components of sexual behavior in male rats. To this end, it analyzed the copulatory parameters and sexual incentive motivation (SIM) of rats treated with CMI under two conditions: basal and post-hormone replacements. Neonatal treatment with CMI did not affect plasma testosterone or 17?-estradiol concentrations, but did decrease both the consummatory component and sexual motivation according to the results of the SIM test. These aspects were recovered after administering 17?-estradiol +. 5-?-dihydrotestosterone, but not testosterone. " 2014 Elsevier Inc.",,,,,,"10.1016/j.yhbeh.2014.09.014",,,"http://hdl.handle.net/20.500.12104/41962","http://www.scopus.com/inward/record.url?eid=2-s2.0-84911477975&partnerID=40&md5=3d67ee9b070f9e6b2ae8fdd4b7d0942b
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25449595",,,,,,"5",,"Hormones and Behavior",,"820
827",,"66",,"Scopus
WOS
MEDLINE",,,,"Index Medicus",,"17?-estradiol; Clomipramine (CMI); Depression; Gonadal hormones; Motivation; Sexual behavior",,,,,,"Hormone replacement with 17?-estradiol plus dihydrotestosterone restores male sexual behavior in rats treated neonatally with clomipramine",,"Article" "45125","123456789/35008",,"Bautista, F., Departamento De Ingeniería Química -- CUCEI, Universidad De Guadalajara, Boul. M. García Barragan # 1451, Guadalajara, Jal. 44430, Mexico; Soltero, J.F.A., Departamento De Ingeniería Química -- CUCEI, Universidad De Guadalajara, Boul. M. García Barragan # 1451, Guadalajara, Jal. 44430, Mexico; Pérez-López, J.H., Departamento De Ingeniería Química -- CUCEI, Universidad De Guadalajara, Boul. M. García Barragan # 1451, Guadalajara, Jal. 44430, Mexico; Puig, J.E., Departamento De Ingeniería Química -- CUCEI, Universidad De Guadalajara, Boul. M. García Barragan # 1451, Guadalajara, Jal. 44430, Mexico; Manero, O., Instituto De Investigaciones En Materiales, Universidad Nacional Autónoma De México, Apdo. Postal 70-360, México, D.F. 04510, Mexico",,"Bautista, F.
Soltero, J.F.A.
Perez-Lopez, J.H.
Puig, J.E.
Manero, O.",,"2000",,"Under steady shear flow, elongated micellar solutions show shear stress saturation above a critical shear rate due to the formation of shear bands that result in non-homogeneous flow. Long transients and oscillations accompany this stress plateau. When measurements are done with a controlled stress rheometer, frequently a metastable branch is observed. At higher shear rates, a second upturn is observed above a second critical shear rate, which indicates that homogeneous flow is recovered. Here, a model consisting of the codeformational Maxwell constitutive equation coupled to a kinetic equation to account for the breaking and reformation of the micelles is presented to reproduce the features described above in steady shear flow. The model also predicts a second metastable branch and long transients at higher shear rates and the existence of an inflexion point in stress-shear rate plots above which no shear banding behavior is detected. (C) 2000 Elsevier Science B.V. All rights reserved.Under steady shear flow, elongated micellar solutions show shear stress saturation above a critical shear rate due to the formation of shear bands that result in non-homogeneous flow. Long transients and oscillations accompany this stress plateau. When measurements are done with a controlled stress rheometer, frequently a metastable branch is observed. At higher shear rates, a second upturn is observed above a second critical shear rate, which indicates that homogeneous flow is recovered. Here, a model consisting of the codeformational Maxwell constitutive equation coupled to a kinetic equation to account for the breaking and reformation of the micelles is presented to reproduce the features described above in steady shear flow. The model also predicts a second metastable branch and long transients at higher shear rates and the existence of an inflexion point in stress-shear rate plots above which no shear banding behavior is detected.",,,,,,"10.1016/S0377-0257(00)00128-2",,,"http://hdl.handle.net/20.500.12104/43346","http://www.scopus.com/inward/record.url?eid=2-s2.0-0034333503&partnerID=40&md5=74fcd5e77bc8e3a5f8ed28b3b29c98ca",,,,,,"1",,"Journal of Non-Newtonian Fluid Mechanics",,"57
66",,"94",,"Scopus
WOS",,,,,,"Codeformational Maxwell constitutive equation; Micellar solutions; Steady shear flow",,,,,,"On the shear banding flow of elongated micellar solutions",,"Article" "43748","123456789/35008",,"Fofanov, Y., Department of Computer Science, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States; Luo, Y., Department of Computer Science, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States; Katili, C., Department of Computer Science, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States; Wang, J., Department of Computer Science, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States; Belosludtsev, Y., Vitruvirus Biosciences, Woodlands, TX, United States; Powdrill, T., Vitruvirus Biosciences, Woodlands, TX, United States; Belapurkar, C., Department of Computer Science, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States; Fofanov, V., Department of Computer Science, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States; Li, T.-B., Department of Computer Science, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States; Chumakov, S., Department of Computer Science, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States, Department of Physics, University of Guadalajara, Guadalajara, Mexico; Pettitt, B.M., Department of Computer Science, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States, Department of Chemistry, University of Houston, 4800 Calhoun Road, Houston, TX 77204-3010, United States",,"Fofanov, Y.
Luo, Y.
Katili, C.
Wang, J.
Belosludtsev, Y.
Powdrill, T.
Belapurkar, C.
Fofanov, V.
Li, T.-B.
Chumakov, S.
Pettitt, B.M.",,"2004",,"Motivation: Analysis of statistical properties of DNA sequences is important for evolutional biology as well as for DNA probe and PCR technologies. These technologies, in turn, can be used for organism identification, which implies applications in the diagnosis of infectious diseases, environmental studies, etc. Results: We present results of the correlation analysis of distributions of the presence/absence of short nucleotide subsequences of different length ('n-mers', n = 5 - 20) in more than 1500 microbial and virus genomes, together with five genomes of multicellular organisms (including human). We calculate whether a given n-mer is present or absent (frequency of presence) in a given genome, which is not the usually calculated number of appearances of n-mers in one or more genomes (frequency of appearance). For organisms that are not close relatives of each other, the presence/absence of different 7-20mers in their genomes are not correlated. For close biological relatives, some correlation of the presence of n-mers in this range appears, but is not as strong as expected. Suppressed correlations among the n-mers present in different genomes leads to the possibility of using random sets of n-mers (with appropriately chosen n) to discriminate genomes of different organisms and possibly individual genomes of the same species including human with a low probability of error. " Oxford University Press 2004; all rights reserved.
URI: http://hdl.handle.net/20.500.12104/41969
http://www.scopus.com/inward/record.url?eid=2-s2.0-7244254459&partnerID=40&md5=cb75a97f200648f634285a9a1071f79a
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