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|Title:||History, theory and communication research [Historia, teoría e investigación de la communication]|
|Abstract:||Systemic lupus erythematosus (SLE) is an autoimmune disease in which polymorphisms within the human leukocyte antigen (HLA) region have been associated to its etiology. For this study, HLA-DQB1, DQA1, and DRB1 genes were typed by polymerase chain reaction-sequence-specific primer in 237 individuals, taken from 74 families, who had a member with SLE, and who had their residence in the western region of Mexico; as well as in 159 ethnically matched healthy volunteers taken from 32 families. Genotype and allele frequency analysis was performed in 74 SLE patients and 54 unrelated controls. Precise three-loci identification of independent haplotypes was performed in 48 patients and 54 controls by familial segregation. Genotype distribution at each loci was concordant with Hardy-Weinberg's equilibrium in the control group. In general, no genotype effect was observed in SLE patients. Allele distribution comparison showed in the SLE group a significant increase of HLA-DQA1*0102, DQB1*0402, and DRB1*15; whereas alleles HLA-DQB1*0303 and *0501 were significantly decreased. SLE patients showed haplotype DQB1*0602-DQA1-*0102-DRB1*15 increased. As expected, patients with SLE have a reduced haplotype genetic diversity. The associations found in this study are related to an ancestral haplotype that has been observed in SLE populations of different origins. " American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc.",,,,,,"10.1016/j.humimm.2004.09.008",,,"http://hdl.handle.net/20.500.12104/41942","http://www.scopus.com/inward/record.url?eid=2-s2.0-10444268050&partnerID=40&md5=fe1a553053545d6294351a771f21c624",,,,,,"12",,"Human Immunology",,"1469|
WOS",,,,,,"association study; Haplotype; HLA class II; systemic lupus erythematosus",,,,,,"HLA class II haplotypes in Mexican systemic lupus erythematosus patients",,"Article" "43720","123456789/35008",,"Vidales Gonzáles, C., Universidad de Guadalajara, Mexico, Zapopan, Mexico",,"Vidales Gonzales, C.",,"2015",,"The article proposes a critical overview of contemporary communication history, theory and research in order to transit from genealogical reconstructions of the field, toward reconstructions grounded in objects of knowledge. It also analyzes the emergence of subfields of knowledge and the role history has had in the constitution of the field of communication, its history and research practice. " 2015, Universidad de Guadalajara. All rights reserved.
|Appears in Collections:||Producción científica UdeG|
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