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Title: Hepatitis C virus infection and type 2 diabetes mellitus in Mexican patients.
Author: Chiquete, E.
Ochoa-Guzman, A.
García-Lamas, L.
Anaya-Gomez, F.
Gutierrez-Manjarrez, J.I.
Sanchez-Orozco, L.V.
Godinez-Gutierrez, S.A.
Maldonado, M.
Roman, S.
Panduro-Cerda, Arturo
Issue Date: 2012
Abstract: to measure the frequency of type 2 diabetes mellitus (T2DM) in patients with confirmed HCV infection. we studied 125 adults reactive to anti-HCV antibodies (62.4 % women, mean age 46.8 years) who received confirmatory RT-PCR testing for viremia (63.2 % HCV-RNA-positive). twenty-two patients had T2DM (17.6 %, 95 % confidence interval: 11.8-25.3 %; mean National prevalence: 14.4 %), more frequent among patients with detectable viremia than in negative cases (23.3 % vs. 9.6 %, respectively; p = 0.04), and among those with advanced liver disease, than in compensated patients (28.9 % vs. 11.3 %, respectively; p = 0.01). Fourteen (17.7 %) patients received interferon-based treatment and 6 (42.8 %) had sustained virology response. None of the 6 responders had T2DM, but 2 of the 8 (25 %) non-responders had diabetes. T2DM patients were older than those without diabetes (57.7 vs. 44.5 years, p < 0.001), and after multivariate analysis, only age was significantly associated with diagnosis of T2DM. T2DM was highly prevalent among patients with chronic HCV infection. Age was the most important determining factor.
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