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|Title:||HANOIPC3: A computer program to evaluate executive functions|
|Abstract:||Objective. We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease. Methods. We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology. Results. The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (? = 0.3; 95CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI) (? = 0.2; 95CI: 0.1, 0.3; P 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype. Conclusions. The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico. " 2012 América Martínez-Calleja et al.",,,,,,"10.1155/2012/982683",,,"http://hdl.handle.net/20.500.12104/41842","http://www.scopus.com/inward/record.url?eid=2-s2.0-84867795149&partnerID=40&md5=e7809c40389eb6e731a1ebc6a934179e",,,,,,,,"Experimental Diabetes Research",,,,"2012",,"Scopus|
WOS",,,,,,,,,,,,"Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from southwestern Mexico",,"Article" "43610","123456789/35008",,"Sánchez, D.A.G., Posgrado en la Wakc Forest University, Carolina Del Norte, Posgrado en Enfermedades Del Pelo y Cosmética, Mexico; Alfaro, N., C Del Instituto Regional de Investigación en Salud Pública, Universidad de Guadalajara, Dermatología, Posgrado en Dermatología Pediátrica, Guadalajara, Jalisco, Mexico; Sandoval-Tress, C., Hospital General de Zona 42, Instituto Mexicano Del Seguro Sodal, Puerto Vallarta, Jalisco, Mexico",,"Sanchez, D.A.G.
Sandoval-Tress, C.",,"2010",,"The aim of the present article is to review the hair's anatomy, histology, embriology, growth, and development Also, we discuss molecular biology basic aspects and the molecular mechanisms regulating the hair's morphogenesis and development Currently, it is necessary to know about the hair's anatomy and molecular structure in order to design new treatments for alopecias. Hair loss affects most of the world population.",,,,,,,,,"http://hdl.handle.net/20.500.12104/41831","http://www.scopus.com/inward/record.url?eid=2-s2.0-77950357477&partnerID=40&md5=c39683268b215e196798c71af54eb41c",,,,,,"1",,"Dermatologia Cosmetica, Medica y Quirurgica",,"54
61",,"8",,"Scopus",,,,,,"Hair; Hair follicle; Morphogenesis",,,,,,"Hair's molecular structure and development [Estructura molecular y desarrollo del pelo]",,"Article" "43618","123456789/35008",,"Guevara, M.A., Instituto de Neurociencias, Universidad de Guadalajara, Francisco Quevedo 180, Colonia Arcos Vallarta, C.P. 44130 Guadalajara, Jalisco, Mexico; Rizo, L., Instituto de Neurociencias, Universidad de Guadalajara, Francisco Quevedo 180, Colonia Arcos Vallarta, C.P. 44130 Guadalajara, Jalisco, Mexico; Ruiz-Díaz, M., Instituto de Neurociencias, Universidad de Guadalajara, Francisco Quevedo 180, Colonia Arcos Vallarta, C.P. 44130 Guadalajara, Jalisco, Mexico; Hernández-González, M., Instituto de Neurociencias, Universidad de Guadalajara, Francisco Quevedo 180, Colonia Arcos Vallarta, C.P. 44130 Guadalajara, Jalisco, Mexico",,"Guevara, M.A.
Hernandez-Gonzalez, M.",,"2009",,"This article describes a computer program (HANOIPC3) based on the Tower of Hanoi game that, by analyzing a series of parameters during execution, allows a fast and accurate evaluation of data related to certain executive functions, especially planning, organizing and problem-solving. This computerized version has only one level of difficulty based on the use of 3 disks, but it stipulates an additional rule: only one disk may be moved at a time, and only to an adjacent peg (i.e., no peg can be skipped over). In the original version - without this stipulation - the minimum number of movements required to complete the task is 7, but under the conditions of this computerized version this increases to 26. HANOIPC3 has three important advantages: (1) it allows a researcher or clinician to modify the rules by adding or removing certain conditions, thus augmenting the utility and flexibility in test execution and the interpretation of results; (2) it allows to provide on-line feedback to subjects about their execution; and, (3) it creates a specific file to store the scores that correspond to the parameters obtained during trials. The parameters that can be measured include: latencies (time taken for each movement, measured in seconds), total test time, total number of movements, and the number of correct and incorrect movements. The efficacy and adaptability of this program has been confirmed. " 2009 Elsevier Ireland Ltd. All rights reserved.
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