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|Title:||Genotype and allele frequency of PAI-1 promoter polymorphism in healthy subjects from the west of Mexico. Association with biochemical and hematological parameters|
|Abstract:||The genotypes and subtypes of 15 Mexican hepatitis B virus strains were determined by sequencing and phylogenetic analysis of the small S-gene. The most predominant strains were found to be divergent genotype/subtype F/adw4 strains (66.6%), followed by A/adw2 (20.0%), D/ayw3 (6.7%), and G/adw2 (6.7%). The S-genes of the Mexican genotype F strains and two Nicaraguan strains described previously formed a subcluster with more than 4% divergence from the other strains within this genotype. The Mexican strains within genotypes A and D showed the highest homology with strains from Europe and the United States. Ten amino acid substitutions not described previously were found in the S-genes of strains from nine chronic carriers, whereas the S gene in strains from six acute hepatitis B patients were highly conserved as compared to their respective genotypes. One genotype F strain from an HBsAg positive chronic carrier had a T to A mutation at position 647, forming a translational stop at codon 216. Two genotype F strains from HBsAg negative chronic carriers had a Val180 instead of an Ala found in the other genotype F strains. This study shows that a divergent genotype F predominates in Mexican strains analyzed, which presented amino acid substitutions not reported previously outside the a determinant. " 2002 Wiley-Liss, Inc.",,,,,,"10.1002/jmv.10166",,,"http://hdl.handle.net/20.500.12104/41735","http://www.scopus.com/inward/record.url?eid=2-s2.0-0036021184&partnerID=40&md5=c8f08e41c98863bd2dddfe714ab0966d",,,,,,"1",,"Journal of Medical Virology",,"24|
WOS",,,,,,"HBsAg; HBV genotype; Small S-gene",,,,,,"Genotypes and S-gene variability of Mexican hepatitis B virus strains",,"Article" "43521","123456789/35008",,"Vargas-Hernández, J.G., University Center for Economic and Managerial Sciences, University of Guadalajara, Periferico Norte N 799, C.P. 45100, Zapopan, Jalisco, Mexico; Sánchez Rico, M.R., University Center for Economic and Managerial Sciences, University of Guadalajara, Periferico Norte N 799, C.P. 45100, Zapopan, Jalisco, Mexico",,"Vargas-Hernandez, J.G.
Sanchez Rico, M.R.",,"2013",,"This paper is aimed to show evidence about unbalanced wealth distribution in Mexico, affording more information, knowledge and sensitivity from citizens and Mexican government on behalf of looking for an equitable economic development and increasing the national welfare are the objective from this investigation. Across the assumption: "The growth of FEMSA from geographical and product diversification cannot be considered as a directly proportional indicator to the increase personal and economic welfare of their workers". Was used a qualitative methodology, running an indicators analysis and FEMSA's workers and former workers interviews. The result was that the assumption is correct being relevant and necessary to generate measures allowing a balanced wealth distribution and a real growth of national economy.",,,,,,"10.5901/mjss.2013.v4n16p111",,,"http://hdl.handle.net/20.500.12104/41742","http://www.scopus.com/inward/record.url?eid=2-s2.0-84900384086&partnerID=40&md5=514cab5bacd0d909038c49d65c019e93",,,,,,"15 SPEC.ISSUE",,"Mediterranean Journal of Social Sciences",,"111
118",,"4",,"Scopus",,,,,,"Geographical diversification; Product diversification; Wealth distribution",,,,,,"Geographic and product diversification facilitating an improper distribution of wealth",,"Article" "43510","123456789/35008",,"Ruiz-Quezada, S., Laboratorio de Inmunología, Ctro. Univ. de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada Street No. 950, Jalisco, Mexico, C.P. 44281, Mexico; Vázquez-Del Mercado, M., Laboratorio de Inmunología, Ctro. Univ. de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada Street No. 950, Jalisco, Mexico, C.P. 44281, Mexico; Parra-Rojas, I., Serv. de Biol. Molecular en Medicina, Hospital Civil Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Rangel-Villalobos, H., Lab. de Genética Molecular, Ctro. Univ. de la Ciénega, Universidad de Guadalajara, Mexico; Best-Aguilera, C., Servicio de Hematología, Hospital General de Occidente, Zapopan, Jalisco, Mexico; Sánchez-Orozco, L.V., Serv. de Biol. Molecular en Medicina, Hospital Civil Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Muñoz-Valle, J.F., Laboratorio de Inmunología, Ctro. Univ. de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada Street No. 950, Jalisco, Mexico, C.P. 44281, Mexico",,"Ruiz-Quezada, S.
Vazquez-Del Mercado, M.
Munoz-Valle, J.F.",,"2004",,"We investigated the genotype and allelic frequency of the -675 bp insertion/deletion polymorphism at the PAI-1 gene promoter, in healthy Mexican subjects. It was compared to the lipid profile and hematological parameters, and to other healthy worldwide populations. A Mexican population sample of 110 individuals was studied. Demographic data and clinical characteristics of the subjects were registered. Fasting lipid profile, serum glucose, fibrinogen, hematological parameters and leukocyte genomic DNA isolation from peripheral blood were performed in all the participants. Screening of the PAI-1 genotype was done by PCR and restriction analysis. Genotype 4G/4G, 4G/5G, 5G/5G frequency in Mexican healthy subjects was: 14.55%, 39.09%, 46.36%, respectively, whereas the allelic frequency for 5G allele was 65.9%. A significant lesser frequency for 4G allele and related genotypes (4G/4G and 4G/5G) was established in healthy subjects from Mexico, respect to all the compared populations. A particular genotype and allelic frequency of this PAI-1 polymorphism was established in Mexico. The clinical parameters were not associated according to each genotype of PAI-1. " 2004 Elsevier SAS. All rights reserved.
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