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|Title:||Genetic profile of overweight and obese school-age children|
|Abstract:||We report autosomal STR data (Identifiler® PCR amplification kit) of a total sample of 884 unrelated Mestizos from three different regions of Mexico. The population sample included 309, 313 and 262 individuals from the states of Jalisco (West), Puebla (Center) and Yucatan (Southeast), respectively. Allele distribution and forensic statistical parameters are described. Genotype distribution by locus and two-loci combination was in agreement with Hardy-Weinberg expectations for all 15 STRs. Pairwise comparisons including Mexican populations reported in the literature demonstrated a significant differentiation, principally between North/West with regard to Center/Southeast Mexico. These results increase STR data from previously unreported regions of this country, and constitute a valuable guide in forensic casework for choosing an auxiliary STR database in states where it is not available. " 2008 Elsevier Ireland Ltd. All rights reserved.",,,,,,"10.1016/j.fsigen.2008.07.006",,,"http://hdl.handle.net/20.500.12104/41694","http://www.scopus.com/inward/record.url?eid=2-s2.0-67349187934&partnerID=40&md5=dba4b28eb2c143f0bc42be828179fb06|
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=19414155",,,,,,"3",,"Forensic Science International: Genetics",,"e71
WOS",,,,"Index Medicus;Alleles;Ethnic Groups/ge [Genetics];Forensic Genetics;Gene Frequency;Genetics, Population;Genotype;Geography;Humans;Indians, North American/ge [Genetics];Mexico;Microsatellite Repeats;Nucleic Acid Amplification Techniques;Polymerase Chain Reaction",,"Forensic; Identifiler; Mestizos; Mexico; STR",,,,,,"Genetic data of 15 autosomal STRs (Identifiler kit) of three Mexican Mestizo population samples from the States of Jalisco (West), Puebla (Center), and Yucatan (Southeast)",,"Article" "43486","123456789/35008",,"Torres-Bugarín, O., Departmento de Morfología, Facultad de Medicina, Departamento de Investigación, Universidad Autónoma de Guadalajara, Zapopan, Jalisco, Mexico; Fernández-García, A., Maestría en Nutrición Clínica, Universidad del Valle de Atemajac, Guadalajara, Jalisco, Mexico; Torres-Mendoza, B.M., Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara y Universidad del Valle de Atemajac, Guadalajara, Jalisco, Mexico; Zavala-Aguirre, J.L., Escuela de Biología, Universidad Autónoma de Guadalajara, Guadalajara, Jalisco, Mexico; Nava-Zavala, A., Departmento de Morfología, Facultad de Medicina, Departamento de Investigación, Universidad Autónoma de Guadalajara, Zapopan, Jalisco, Mexico; Zamora-Perez, A.L., Instituto de Investigacio ?n en Odontología, Departamento de Clínicas Odontológicas Integrales, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico",,"Torres-Bugarin, O.
Zamora-Perez, A.L.",,"2009",,"Obesity is associated with overproduction of free radicals that promotes genotoxicity and could be measured as micronuclei (MN) and nuclear abnormalities (NA) in buccal mucosa cells. The frequency of MN and NA in buccal mucosa cells from overweight and obesity school-age children was determined. In a cross-sectional study, four anthropometric parameters were obtained from each child and one buccal mucosa sample was collected from each child. The slides were stained with orcein and fast green and microscopically analyzed for MN and NA. Twenty overweight and obesity school-age children (7-11 years old) from three schools located at the metropolitan area of Guadalajara were selected to form three groups with 20 children each, according to the weight features as follows: (1) normal weight; (2) overweight; and (3) obesity. No marked differences were found between groups for frequency of MN and NA. Genotoxicity, as indicated by increase in binucleated (BN) cells, was found in children within both overweight and obese groups exposed to passive tobacco smoke. There was no evidence of genetic instability in overweight and obese school-age children and no associations between body weight and genotoxicity markers found. " 2009 Taylor & Francis.
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