Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41642
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dc.contributor.authorNoriega-Ortega, B.R.-
dc.contributor.authorArmienta-Aldana, E.-
dc.contributor.authorCervantes-Pompa, J., A.-
dc.contributor.authorArmienta-Aldana, E.-
dc.contributor.authorHernandez-Ruiz, E.-
dc.contributor.authorChaparro-Huerta, V.-
dc.contributor.authorBravo-Cuellar, A.-
dc.contributor.authorBeas-Zárate, Carlos-
dc.date.accessioned2015-09-15T18:01:07Z-
dc.date.available2015-09-15T18:01:07Z-
dc.date.issued2011-
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-83255192484&partnerID=40&md5=6689b5d12199e3eff7f511850f8da47e-
dc.identifier.urihttp://hdl.handle.net/20.500.12104/41642-
dc.description.abstractOrganophosphates such as methamidophos, usually used in the agricultural field, have harmful effects on humans. Exposures to insecticides has been associated with many disorders, including damage to the central and peripheral nervous system. Chronic exposure to organophosphates may lead to persistent neurological and neurobehavioral effects. This study was conducted to determine the effect of methamidophos on [3H]-dopamine (DA) and gamma aminobutyric acid (GABA) release from different brain regions after chronic exposure to it for 3, 6 or 9 months. After a six-month methamidophos treatment, the mice showed high susceptibility to convulsive seizures and a reduction in stimulated gamma aminobutyric acid release from the cerebral cortex and hippocampal slices, whereas stimulated (DA) release was slightly decreased from the striatum after three months of methamidophos exposure. The results indicate changes in gamma aminobutyric acid and dopamine neurotransmission, suggesting a specific neuronal damage. © 2011 The Japanese Society of Toxicologic Pathology.-
dc.relation.isreferencedbyScopus-
dc.relation.isreferencedbyWOS-
dc.titleGaba and dopamine release from different brain regions in mice with chronic exposure to organophosphate methamidophos-
dc.typeArticle-
dc.identifier.doi10.1293/tox.24.163-
dc.relation.ispartofjournalJournal of Toxicologic Pathology-
dc.relation.ispartofvolume24-
dc.relation.ispartofissue3-
dc.relation.ispartofpage163-
dc.relation.ispartofpage168-
dc.subject.keywordBrain; Chronic toxicity; Dopamine; Gaba; Methamidophos; Neurotransmitter-
dc.contributor.affiliationNoriega-Ortega, B.R., Facultad de Medicina, Universidad Autónoma de Sinaloa (UAS), Culiacán, Sinaloa, Mexico; Armienta-Aldana, E., Facultad de Medicina, Universidad Autónoma de Sinaloa (UAS), Culiacán, Sinaloa, Mexico; Cervantes-Pompa, J. Á., Facultad de Medicina, Universidad Autónoma de Sinaloa (UAS), Culiacán, Sinaloa, Mexico; Armienta-Aldana, E., Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa (UAS), Culiacán, Sinaloa, Mexico; Hernández-Ruíz, E., Departamento de Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (U de G), Guadalajara, Jalisco, Mexico; Chaparro-Huerta, V., Laboratorio de Neurobiología Celular y Molecular, División de Neurociencias, Centro de Investigacion Biomedica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico; Bravo-Cuellar, A., Laboratorio de Inmunología de los Tumores, División de Inmunología, Centro de Investigacion Biomedica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico; Beas-Zárate, C., Laboratorio de Neurobiología Celular y Molecular, División de Neurociencias, Centro de Investigacion Biomedica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico, Departamento de Biología Celular y Molecular, Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), Universidad de Guadalajara (U de G), Guadalajara, Jalisco, Mexico-
dc.contributor.affiliationBeas-Zárate, Carlos., Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias-
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