Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41535
Title: Fish oil, melatonin and vitamin e attenuates midbrain cyclooxygenase-2 activity and oxidative stress after the administration of 1-methyl-4-phenyl-1,2, 3,6- tetrahydropyridine
Author: Raddi, R.
Drew, J.E.
Fabregat, J.
Steeghs, D.
Wright, N.J.
Sale, S.E.
Farnhill, H.J.
Barlow, M.J.
Greimel, R.
Sabin, L.
Corradi, R.M.L.
Drake, J.J.
Issue Date: 2013
Abstract: We investigate a region of the Galactic plane, between 120 ? l ? 140 and-1 ? b?+4 , and uncover a population of moderately reddened (E(B-V) ~ 1) classical Be stars within and beyond the Perseus and Outer Arms. 370 candidate emission-line stars (13?r?16) selected from the Isaac Newton Telescope Photometric Ha Survey of the Northern Galactic plane have been followed up spectroscopically. A subset of these, 67 stars with properties consistent with those of classical Be stars, have been observed at sufficient spectral resolution (?? ? 2-4 ) at blue wavelengths to narrow down their spectral types. We determine these to a precision estimated to be 1 subtype and then we measure reddenings via spectral energy distribution fitting with reference to appropriate model atmospheres. Corrections for contribution to colour excess from circumstellar discs are made using an established scaling to Ha emission equivalent width. Spectroscopic parallaxes are obtained after luminosity class has been constrained via estimates of distances to neighbouring A/F stars with similar reddenings. Overwhelmingly, the stars in the sample are confirmed as luminous classical Be stars at heliocentric distances ranging from 2 kpc up to ~12 kpc. However, the errors are presently too large to enable the cumulative distribution function with respect to distance to distinguish between models placing the stars exclusively in spiral arms, or in a smooth exponentially declining distribution. " 2013 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.",,,,,,"10.1093/mnras/stt038",,,"http://hdl.handle.net/20.500.12104/41535","http://www.scopus.com/inward/record.url?eid=2-s2.0-84876811129&partnerID=40&md5=7c537a0a3a76c0f1bd980e198a951b74",,,,,,"3",,"Monthly Notices of the Royal Astronomical Society",,"2169
2187",,"430",,"Scopus
WOS",,,,,,"Dust, extinction; Galaxy:structure; ISM:structure; Stars:early-type; Stars:emission-line, Be",,,,,,"First results of an H? based search of classical Be stars in the Perseus Arm and beyond",,"Article" "43319","123456789/35008",,"Ortiz, G.G., Laboratorio de Mitocondria-Estrés Oxidativo and Patología, División de Neurociencias, Instituto Mexicano Del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico; Pacheco-Moisés, F.P., Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Marcelino García Barragan y Calzada Olimpica, CP 44340 Guadalajara, Jalisco, Mexico; Gómez-Rodríguez, V.M., Laboratorio de Mitocondria-Estrés Oxidativo and Patología, División de Neurociencias, Instituto Mexicano Del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico; González-Renovato, E.D., Laboratorio de Mitocondria-Estrés Oxidativo and Patología, División de Neurociencias, Instituto Mexicano Del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico; Torres-Sánchez, E.D., Laboratorio de Mitocondria-Estrés Oxidativo and Patología, División de Neurociencias, Instituto Mexicano Del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico; Ramírez-Anguiano, A.C., Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Marcelino García Barragan y Calzada Olimpica, CP 44340 Guadalajara, Jalisco, Mexico",,"Ortiz, G.G.
Pacheco-Moises, F.P.
Gomez-Rodriguez, V.M.
Gonzalez-Renovato, E.D.
Torres-Sanchez, E.D.
Ramirez-Anguiano, A.C.",,"2013",,"Parkinson's disease is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. Ciclooxygenase-2 activity induction and oxidative stress have been implicated in the aetiology of Parkinson's disease and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of Parkinson disease. Upon administration of fish oil, melatonin and vitamin E, neuroprotective effects on MPTP-induced neurotoxicity have been indicated. The aim of this study was to investigate the time course and compare the potency of these agents alone, on several parameters such as COX-2 and lipid peroxides (LPO) products associated with MPTP neurotoxicity in midbrain homogenates of C57BL/6 mice. Using fish oil (0.0368 g EPA and 0.0184 g DHA, per day), melatonin (10 mg/kg/day), and vitamin E (50 mg/Kg/day) we have now shown that COX-2 activity, LPO and nitrite/nitrate levels were significantly increased in MPTP treated mice (p < 0.001) while fish oil, melatonin and vitamin E treatment were capable of decreasing significantly the outcome of all above noted parameters (p < 0.05). The effect of fish oil on COX-2 activity and nitrite/nitrate levels was more profound than that of vitamin E or melatonin while the latter was more effective on reducing the LPO levels compared to fish oil and vitamin E. In conclusion, the outcome of the neuroprotective effects of these agents is long lasting and of variable potency indicating a different anti-inflammatory mode of action. " 2013 Springer Science+Business Media New York.
URI: http://hdl.handle.net/20.500.12104/41540
http://www.scopus.com/inward/record.url?eid=2-s2.0-84887247980&partnerID=40&md5=0ef7291206a5cbacec07e42ab9ce0a34
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