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|Title:||Non-negative Wigner functions for orbital angular momentum states|
|Abstract:||Low BRCA1 gene expression is associated with increased invasiveness and influences the response of breast carcinoma (BC) to chemotherapeutics. However, expression of BRCA1 and BRCA2 genes has not been completely characterized in premenopausal BC. We analyzed the clinical and immunohistochemical correlates of BRCA1 and BRCA2 expression in young BC women. We studied 62 women (mean age 38.8 years) who developed BC before the age of 45 years. BRCA1 and BRCA2 mRNA expression was assessed by reverse transcriptase-polymerase chain reaction (RT-PCR) and that of HER-2 and p53 proteins by immunohistochemistry. Body mass index (BMI) ?27 (52%) and a declared family history of BC (26%) were the main risk factors. Ductal infiltrative adenocarcinoma was found in 86% of the cases (tumor size >5 cm in 48%). Disease stages I-IV occurred in 2, 40, 55, and 3%, respectively (73% implicating lymph nodes). Women aged ?35 years (24%) had more family history of cervical cancer, stage III/IV disease, HER-2 positivity, and lower BRCA1 expression than older women (P < 0.05). BRCA1 and BRCA2 expression correlated in healthy, but not in tumor tissues (TT). Neither BRCA1 nor BRCA2 expression was associated with tumor histology, differentiation, nodal metastasis or p53 and HER-2 expression. After multivariate analysis, only disease stage explained BRCA1 mRNA levels in the lowest quartile. Premenopausal BC has aggressive clinical and molecular characteristics. Low BRCA1 mRNA expression is associated mainly with younger ages and advanced clinical stage of premenopausal BC. BRCA2 expression is not associated with disease severity in young BC women. " 2008 Humana Press Inc.",,,,,,"10.1007/s12032-008-9114-7",,,"http://hdl.handle.net/20.500.12104/41418","http://www.scopus.com/inward/record.url?eid=2-s2.0-77954086867&partnerID=40&md5=68a42fdc0ca8672d78549b60083b2204|
WOS",,,,"Index Medicus;Adult;Apoptosis Regulatory Proteins;BRCA1 Protein/bi [Biosynthesis];BRCA1 Protein/ge [Genetics];BRCA2 Protein/bi [Biosynthesis];BRCA2 Protein/ge [Genetics];Breast Neoplasms/ge [Genetics];Breast Neoplasms/me [Metabolism];Breast Neoplasms/pa [Pathology];Chi-Square Distribution;Female;Gene Expression Profiling;Humans;Immunohistochemistry;Logistic Models;Mexico;Premenopause/ge [Genetics];Premenopause/me [Metabolism];Risk Factors;Young Adult",,"BRCA1; BRCA2; Breast carcinoma; Gene expression; Mexico; mRNA",,,,,,"Expression profile of BRCA1 and BRCA2 genes in premenopausal Mexican women with breast cancer: Clinical and immunohistochemical correlates",,"Article" "44988","123456789/35008",,"Rigas, I., Departamento de óptica, Facultad de Física, Universidad Complutense, E-28040 Madrid, Spain; Sánchez-Soto, L.L., Departamento de óptica, Facultad de Física, Universidad Complutense, E-28040 Madrid, Spain; Klimov, A.B., Departamento de Física, Universidad de Guadalajara, 44420 Guadalajara, Jalisco, Mexico; R eh ek, J., Department of Optics, Palacký University, 17. listopadu 50, CZ-772 00 Olomouc, Czech Republic; Hradil, Z., Department of Optics, Palacký University, 17. listopadu 50, CZ-772 00 Olomouc, Czech Republic
Klimov, Andrei B., Universidad de Guadalajara. Centro Universitario de Ciencias Exactas e Ingenierías",,"Rigas, I.
Klimov, Andrei B.
Hradil, Z.",,"2010",,"The Wigner function of a pure continuous-variable quantum state is non-negative if and only if the state is Gaussian. Here we show that for the canonical pair angle and angular momentum, the only pure states with non-negative Wigner functions are the eigenstates of the angular momentum. Some implications of this surprising result are discussed. " 2010 The American Physical Society.
|Appears in Collections:||Producción científica UdeG|
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