Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41225
Title: Electroweak scale neutrinos and decaying dark matter
Author: Tellez-Banuelos, M.C.
Ortiz-Lazareno, P.C.
Jave-Suarez, L.F.
Siordia-Sanchez, V.H.
Bravo-Cuellar, A.
Santerre, A.
Zaitseva, G.P.
Issue Date: 2014
Abstract: The effect of the organochlorinated insecticide endosulfan, on the cytotoxic activity of Nile tilapia nonspecific cytotoxic cells (NCC) was assessed. Juvenile Nile tilapia were exposed to endosulfan (7ppb) for 96h and splenic NCC were isolated. Flow cytometric phenotyping of NCC was based on the detection of the NCC specific membrane signaling protein NCCRP-1 by using the monoclonal antibody Mab 5C6; granzyme expression was evaluated by quantitative RT-PCR. The cytotoxic activity of sorted NCC on HL-60 tumoral cells was assessed using propidium iodide (PI) staining of DNA in HL-60 nuclei, indicating dead cells. Nile tilapia splenic NCC had the ability to kill HL-60 tumoral cells, however, the exposure to endosulfan significantly reduced, by a 65%, their cytotoxic activity when using the effector:target ratio of 40:1. Additionally, the exposure to endosulfan tended to increase the expression of NCCRP-1, which is involved in NCC antigen recognition and signaling. Moreover, it decreased the expression of the granzyme gene in exposed group as compared with non-exposed group; however significant differences between groups were not detected. In summary, the acute exposure of Nile tilapia to sublethal concentration of endosulfan induces alteration in function of NCC: significant decrease of cytotoxic activity and a tendency to lower granzyme expression, severe enoughto compromise the immunity of this species. " 2014 Elsevier Ltd.",,,,,,"10.1016/j.fsi.2014.03.012",,,"http://hdl.handle.net/20.500.12104/41225","http://www.scopus.com/inward/record.url?eid=2-s2.0-84898846292&partnerID=40&md5=ecb997c041587f43fbe0c4f6add677ee
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=24657320",,,,,,"1",,"Fish and Shellfish Immunology",,"196
203",,"38",,"Scopus
WOS
MEDLINE",,,,"Index Medicus;Animals;Cichlids;Cytotoxicity, Immunologic/de [Drug Effects];Endosulfan/to [Toxicity];Gene Expression Regulation, Enzymologic/de [Drug Effects];Granzymes/ge [Genetics];Granzymes/me [Metabolism];HL-60 Cells;Humans;Insecticides/to [Toxicity];Spleen/cy [Cytology]",,"Cytotoxic activity; Endosulfan; Granzyme; NCC; Nile tilapia",,,,,,"Endosulfan decreases cytotoxic activity of nonspecific cytotoxic cells and expression of granzyme gene in Oreochromis niloticus",,"Article" "44898","123456789/35008",,"Dixon, T., Rosenstiel School for Marine and Atmospheric Sciences, University of Miami, Miami, FL, United States; Farina, F., Rosenstiel School for Marine and Atmospheric Sciences, University of Miami, Miami, FL, United States; DeMets, C., Department Geology and Geophysics, University of Wisconsin, Madison, WI, United States; Suarez-Vidal, F., CICESE, Ensenada, Mexico; Fletcher, J., CICESE, Ensenada, Mexico; Marquez-Azua, B., Departmento de Geografia, Universidad de Guadalajara, Mexico; Miller, M., Central Washington University, Ellensburg, WA, United States; Sanchez, O., Instituto de Geofisico, UNAM, Mexico, Mexico; Umhoefer, P., Northern Arizona University, Flagstaff, AZ, United States",,"Dixon, T.
Farina, F.
DeMets, C.
Suarez-Vidal, F.
Fletcher, J.
Marquez-Azua, B.
Miller, M.
Sanchez, O.
Umhoefer, P.",,"2000",,"We use new models for present-day Pacific-North America motion to evaluate the tectonics of offshore regions west of the Californias. Vandenburg in coastal Alta California moves at the Pacific plate velocity within uncertainties (?1 mm/yr) after correcting for strain accumulation on the San Andreas and San Gregorio-Hosgri faults with a model that includes a viscoelastic lower crust. Modeled and measured velocities at coastal sites in Baja California south of the Agua Blanca fault, a region that most previous models consider Pacific plate, differ by 3-8 mm/yr, with coastal sites moving slower that the Pacific plate. We interpret these discrepancies in terms of strain accumulation on known on-shore faults, combined with right lateral slip at a rate of 3-4 mm/yr on additional faults offshore peninsular Baja California in the Pacific. Offshore seismicity, offset Quaternary features along the west coast of Baja California, and a discrepancy between the magnetically determined spreading rate in the Gulf Rise and the total plate rate from a geological model provide independent evidence for a "Baja California shear zone".We use new models for present-day Pacific-North America motion to evaluate the tectonics of offshore regions west of the Californias. Vandenburg in coastal Alta California moves at the Pacific plate velocity within uncertainties (approx. 1 mm/yr) after correcting for strain accumulation on the San Andreas and San Gregorio-Hosgri faults with a model that includes a viscoelastic lower crust. Modeled and measured velocities at coastal sites in Baja California south of the Agua Blanca fault, a region that most previous models consider Pacific plate, differ by 3-8 mm/yr, with coastal sites moving slower that the Pacific plate. We interpret these discrepancies in terms of strain accumulation on known on-shore faults, combined with right lateral slip at a rate of 3-4 mm/yr on additional faults offshore peninsular Baja California in the Pacific. Offshore seismicity, offset Quaternary features along the west coast of Baja California, and a discrepancy between the magnetically determined spreading rate in the Gulf Rise and the total plate rate from a geological model provide independent evidence for a 'Baja California shear zone'.",,,,,,"10.1029/2000GL008529",,,"http://hdl.handle.net/20.500.12104/43119","http://www.scopus.com/inward/record.url?eid=2-s2.0-0034480792&partnerID=40&md5=a7fb05abba45e9144c278ac31d28bcfc",,,,,,"23",,"Geophysical Research Letters",,"3961
3964",,"27",,"Scopus
WOS",,,,,,,,,,,,"New kinematic models for Pacific-North America motion from 3 MA to present, II: Evidence for a "Baja California shear zone"",,"Article" "42987","123456789/35008",,"Aranda, A., Facultad de Ciencias - CUICBAS, Universidad de Colima, Mexico, Dual C-P Institute of High Energy Physics, Mexico; de Anda, F.J., Departamento de Física - CUCEI, Universidad de Guadalajara, Mexico",,"Aranda, A.
de Anda, F.J.",,"2010",,"We explore the scalar phenomenology of a model of electroweak scale neutrinos that incorporates the presence of a lepton number violating singlet scalar. An analysis of the pseudoscalar-Majoron field associated to this singlet field is carried out in order to verify the viability of the model and to restrict its parameter space. In particular we study the Majoron decay J ? ? ? and use the bounds on the Majoron mass and width obtained in a modified Majoron decaying dark matter scenario. " 2009 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/20.500.12104/41208
http://www.scopus.com/inward/record.url?eid=2-s2.0-73249138623&partnerID=40&md5=bd65f144697ce08f74e64dcaafb34e1e
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