Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/41006
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dc.contributor.authorSanchez-Diaz, J.C.
dc.contributor.authorBecerra-Bracamontes, F.
dc.contributor.authorGonzalez-Alvarez, A.
dc.contributor.authorCruz-Barba, L.E.
dc.contributor.authorMartinez-Ruvalcaba, A.
dc.date.accessioned2015-09-15T17:48:54Z-
dc.date.available2015-09-15T17:48:54Z-
dc.date.issued2010
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-77955947872&partnerID=40&md5=d5a91dafd2f0fbfb7457c100bd080bd3
dc.identifier.urihttp://hdl.handle.net/20.500.12104/41006-
dc.description.abstractAn ionically crosslinked polymer network composed of chitosan and sodium hexametaphosphate (SHMP) was synthesized to determine their swelling and ascorbic acid release kinetics at various SHMP concentrations. The chitosan/SHMP hydrogels were synthesized using an acetic acid aqueous solution (1% v/v). Ionization constants (pKb) of the SHMP were obtained by potentiometric titration. The results show that the SHMP was hydrolyzed in acidic medium forming orthophosphate and trimetaphosphate. The swelling percentages were measured at different swelling media pH's; the higher swelling capacities were for the systems that were swollen in neutral solution. Also, it was studied the ionic crosslinking degree by turbidimetric titration, comparing the electrostatic interactions between the chitosan and the SHMP; the results shows that electrostatic interactions between the amine groups of the chitosan and the anionic groups of the SHMP are dependent of the swelling medium pH. The ascorbic acid diffusion inside the hydrogel follows the second law of Fick, and the diffusion coefficients were obtained for different SHMP concentrations. � 2010 Wiley Periodicals, Inc.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyWOS
dc.titleEffect of sodium hexametaphosphate concentration on the swelling and controlled drug release properties of chitosan hydrogels
dc.typeArticle
dc.identifier.doi10.1002/app.32251
dc.relation.ispartofjournalJournal of Applied Polymer Science
dc.relation.ispartofvolume117
dc.relation.ispartofissue6
dc.relation.ispartofpage3595
dc.relation.ispartofpage3600
dc.subject.keywordChitosan; Drug delivery systems; Hydrogels; Sodium hexametaphosphate; Swelling properties
dc.contributor.affiliationS�nchez-D�az, J.C., Department of Chemical Engineering, University of Guadalajara, Guadalajara 44430, Mexico; Becerra-Bracamontes, F., Department of Chemistry, University of Guadalajara, Guadalajara 44430, Mexico; Gonz�lez-�lvarez, A., Department of Chemical Engineering, University of Guadalajara, Guadalajara 44430, Mexico; Cruz-Barba, L.E., Department of Chemical Engineering, University of Guadalajara, Guadalajara 44430, Mexico; Mart�nez-Ruvalcaba, A., Department of Chemical Engineering, University of Guadalajara, Guadalajara 44430, Mexico
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