Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/40962
Title: Effect of metformin and sibutramine on insulin sensitivity and adiposity in obese patients
Author: Tovar-Cisneros, C.
Gonzlez-Nuez, R.
Rodrigue, D.
Issue Date: 2008
Abstract: In this study, HDPE structural foams are produced by injection molding under different mold temperatures to study the effect of this variable on average cell dimension, cell density, and skin thickness ratio. Samples are also produced by setting independently the temperature of the fixed and moving plate of the mold to detect the sensitivity of foam structure to a temperature gradient in processing. The resulting foams are also characterized in terms of mechanical properties including impact and flexural tests. It has been found that for homogeneous mold temperatures, symmetrical skin thicknesses are obtained, which increase with decreasing mold temperature. On the other hand, by keeping one mold face at a constant temperature and varying the second one, asymmetric skin thicknesses are obtained. The degree of asymmetry is found to increase as the temperature difference between both molds increased. Furthermore, decreasing mold temperature produces a small increase in average cell sizes and reduced cell density. In general, both impact strength and flexural moduli of the structural foams increase with increasing skin thickness. For the particular case of asymmetric foams, the flexural moduli are slightly higher when the load is applied on the thicker skin; while much higher impact strength is obtained when the falling weight strikes the samples on the face having the smaller skin thickness. " SAGE Publications 2008.",,,,,,"10.1177/0021955X07088044",,,"http://hdl.handle.net/20.500.12104/40962","http://www.scopus.com/inward/record.url?eid=2-s2.0-42549132539&partnerID=40&md5=bdbeb0e84da45a57070622263a96205e",,,,,,"3",,"Journal of Cellular Plastics",,"223
237",,"44",,"Scopus
WOS",,,,,,"Flexural modulus; Impact strength; Skin thickness; Structural foam",,,,,,"Effect of mold temperature on morphology and mechanical properties of injection molded HDPE structural foams",,"Article" "42736","123456789/35008",,"Martínez-Abundis, E., Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico, Physiology Department, Health Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico; Valera-González, I.G., Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico; Hernández-Salazar, E., Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico; González-Ortiz, M., Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico, Physiology Department, Health Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico",,"Martinez-Abundis, E.
Valera-Gonzalez, I.G.
Hernandez-Salazar, E.
Gonzalez-Ortiz, M.",,"2010",,"Aims: To compare the effect of metformin and sibutramine as monotherapy or as combined therapy on insulin sensitivity and adiposity in obese patients. Methods: A randomized, double-blind, placebo-controlled clinical trial was performed in 27 patients aged between 18 and 40 years and with a body mass index (BMI) between 30 and 40 kg/m2. Subjects were allocated to receive one of the following interventions: a) placebo and metformin, b) sibutramine and placebo or c) sibutramine and metformin. The intervention was maintained for 90 days and consisted of 15 mg of sibutramine during the morning, 500 mg of metformin during the evening and placebo homologated in accordance with the hour of administration of each group. Estimation of insulin sensitivity by insulin tolerance test and evaluation of fat mass by electrical bioimpedance were performed at the beginning of the study and at 90 days of the study. Results: BMI was reduced in all groups at different magnitudes. Insulin sensitivity was increased in metformin group (3.6 0.9 vs 4.5 1.1%/min; p=0.050). Adiposity decreased significantly in sibutramine group (39.9 7.0 vs 33.0 9.1%; p?0.01). Metformin as monotherapy or combined with sibutramine demonstrated a beneficial effect on lipid profile. Conclusion: The three pharmacological interventions reduced BMI at different magnitudes. Metformin improved insulin sensitivity. Sibutramine decreased adiposity. Metformin as monotherapy or combined with sibutramine had a beneficial effect on lipid profile. ", Editrice Kurtis.
URI: http://hdl.handle.net/20.500.12104/40957
http://www.scopus.com/inward/record.url?eid=2-s2.0-79959794024&partnerID=40&md5=313d94a6b22622a51d617816391321c0
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