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|Title:||Micronucleated erythrocytes in newborns of rat dams exposed to ultraviolet-A light during pregnancy; protection by ascorbic acid supplementation|
De Celis, R.
|Abstract:||Pesticides are frequently used substances worldwide, even when the use of some of them is forbidden due to the recognized adverse effect they have on the health of not only the people who apply the pecticides, but also of those that consume the contaminated products. The objectives of this study were to know the health issues of farm workers chronically exposed to pesticides, to evaluate possible damage at genetic level, as well as to explore some hepatic, renal, and hematological alterations. A transversal comparative study was performed between 2 groups, one composed of 25 farm workers engaged in pesticide spraying, and a control group of 21 workers not exposed to pesticides; both groups belonged to the Nextipac community in Jalisco, Mexico. Each member of both groups underwent a full medical history. Blood samples were taken from all farmworkers in order to obtain a complete blood count and chemistry, clinical chemistry, lipid profile, liver and kidney function tests, erythrocyte cholinesterase quantification, lipid peroxidation profile, and free DNA fragment quantification. For the information analysis, central tendency and dispersion measurements were registered. In order to know the differences between groups, a cluster multivariate method was used, as well as prevalence reasons. The most used pesticides were mainly organophosphates, triazines and organochlorine compounds. The exposed group showed acute poisoning (20% of the cases) and diverse alterations of the digestive, neurological, respiratory, circulatory, dermatological, renal, and reproductive system probably associated to pesticide exposure. More importantly, they presented free DNA fragments in plasma (90.8 vs 49.05 ng/mL) as well as a higher level of lipid peroxidation (41.85 vs. 31.91 nmol/mL) in comparison with those data from unexposed farm workers. These results suggest that there exist health hazards for those farm workers exposed to pesticides, at organic and cellular levels. Copyright " 2012 Taylor & Francis Group, LLC.",,,,,,"10.1080/19338244.2011.564230",,,"http://hdl.handle.net/20.500.12104/40917","http://www.scopus.com/inward/record.url?eid=2-s2.0-84859773763&partnerID=40&md5=d15eba9713935f3e1187ca09befdb440|
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=22315932",,,,,,"1",,"Archives of Environmental and Occupational Health",,"22
MEDLINE",,,,,,"Circulating DNA fragments; Farm workers; Occupational exposure; Pesticides / Core Clinical Journals (AIM), Index Medicus;Adult;Agricultural Workers' Diseases/ci [Chemically Induced];Agricultural Workers' Diseases/ge [Genetics];Agricultural Workers' Diseases/me [Metabolism];Agrochemicals/to [Toxicity];Case-Control Studies;Cholinesterases/me [Metabolism];Cluster Analysis;Cross-Sectional Studies;DNA Fragmentation;Erythrocytes/en [Enzymology];Herbicides/to [Toxicity];Humans;Insecticides/to [Toxicity];Kidney Function Tests;Lipid Peroxidation;Liver Function Tests;Male;Mexico;Middle Aged;Multivariate Analysis;Occupational Exposure/ae [Adverse Effects];Occupational Exposure/an [Analysis];Organophosphates/to [Toxicity]",,,,,,"Effect of chronic pesticide exposure in farm workers of a mexico community",,"Article" "44607","123456789/35008",,"Zúñiga-González, G.M., Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Gómez-Meda, B.C., Instituto de Biología Molecular en Medicina y Terapia Gúnica, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Zamora-Perez, A.L., Instituto de Investigación en Odontología, Departamento de Clínicas Odontológicas Integrales, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Martínez-González, M.A., Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; de Haro, I.A.M., Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Pérez-Navarro, A.E., Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Armendáriz-Borunda, J., Instituto de Biología Molecular en Medicina y Terapia Gúnica, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Gallegos-Arreola, M.P., Laboratorio de Genética Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico",,"Zuniga-Gonzalez, G.M.
de Haro, I.A.M.
Gallegos-Arreola, M.P.",,"2015",,"Pregnant hairless rat dams were exposed to ultraviolet-A light (UVA) to induce micronucleated erythrocytes (MNE) in their fetuses. The control group was exposed to conventional light; the experimental groups were exposed to UVA (365. nm) during gestational days 16-21. In some cases, ascorbic acid (Asc) was administered in the drinking water from gestational day 15 until delivery. Dams were sampled at 48-h intervals during gestation, from day 16 until delivery. Blood was also obtained from neonates at birth; MNE, micronucleated polychromatic erythrocytes (MNPCE), and polychromatic erythrocytes (PCE) were scored. Increased MNE and MNPCE were observed in neonates born to mothers exposed to UVA for 40, 80 or 160. min, compared to the control group. Asc treatment reduced MNE and MNPCE induction. " 2015 Elsevier B.V.
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