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Title: Diagnosis of opportunistic parasites in liver transplantation
Author: de Jesus Romero-Prado, M.M.
Curiel-Beltran, J.A.
Miramontes-Espino, M.V.
Cardona-Munoz, E.G.
Rios-Arellano, A.
Balam-Salazar, L.-B.
Issue Date: 2015
Abstract: Epidemiological studies have suggested that the daily intake of flavonoids is associated with a decreased risk of developing cardiovascular disease. Our purpose was to evaluate the effect of the addition of dietary flavonoids (DF) to antihypertensive treatment (AHT), based on telmisartan (Tms) or captopril (Cpr), on blood pressure (BP), body mass index (BMI), waist/hip ratio, leptin, lipid profile and inflammation in hypertensive young patients. An open-label, randomized, controlled trial was performed among 79 patients aged 20-55 years with grade I or grade II systemic arterial hypertension. The subjects were assigned to one of four groups for AHT plus DF during 6 months: Cpr (n = 14), Cpr + DF (n = 19), Tms (n = 25) and Tms + DF (n = 21). DF consisted of dark chocolate, dehydrated red apple and green tea in an infusion to obtain a daily dose of 425.8 ± 13.9 mg epicatechin equivalents. The BP and anthropometric parameters were measured every 2 weeks. Lipid profile, leptin and hsCRP were determined by standard methods. The combination AHT-DF produced an additional and significant reduction in (i) SBP/DBP of -5/-4 mmHg, being -7/-5 for Cpr + DF and -4/-3 for Tms + DF; (ii) triglyceride levels (-30.6%) versus AHT alone (-9.6%); and (iii) leptin: Cpr + DF versus Tms + DF (p < 0.005). Finally, C-reactive protein plasma levels were reduced significantly in all groups independently of the applied treatment. We conclude that the addition of flavonoids to pharmacological antihypertensive therapy shows additional benefits on BP, lipid profile, leptin, obesity and inflammation. " 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).",,,,,,"10.1111/bcpt.12360",,,"","",,,,,,,,"Basic and Clinical Pharmacology and Toxicology",,,,,,"Scopus
MEDLINE",,,,,,,,,,,,"Dietary flavonoids added to pharmacological antihypertensive therapy are effective in improving blood pressure",,"Article in Press" "38457","123456789/35008",,"Hernández Lomelí, Francisco Universidad de Guadalajara",,"Hernández Lomelí, Francisco Universidad de Guadalajara",,"2006",,,,,,,,,,"0188-252X","",,,"Español",,,,"6",,"Comunicación y sociedad",,"183-187",,,,"CLASE",,,,,,,,"Biografía",,,"Olivares Arriaga, María del Carmen. Emilio Azcárraga Vidaurreta. Bosquejo biográfico, México","Olivares Arriaga, María del Carmen. Emilio Azcárraga Vidaurreta. Bosquejo biográfico, México: Universidad Autónoma de Tamaulipas, 2002",,"journalArticle" "42393","123456789/35008",,"De La Luz Galvan-Ramirez, M., Neurophisiology Laboratory, CUCS, U de G, Jalisco, Mexico; Sánchez, A.R.R., Institute of Chronic and Degenerative Diseases, CUCS, U de G, Jalisco, Mexico; Redondo, R.M.B., Infectology Dept. of Children's Hospital of Mexico Federico Gómez, Mexico",,"De La Luz Galvan-Ramirez, M.
Sanchez, A.R.R.
Redondo, R.M.B.",,"2009",,"At present, organ transplants have become more frequent worldwide. Parasiticinfections can be transmissible by transplantation; human solid organs are vectors tosupport parasitological agents and can transmit infections from donor to recipient. Theprincipal parasitic infections transmitted by liver transplantation are: toxoplasmosis,leishmaniasis, Chagas' disease and malaria.Experience with immunosuppressive patients suggests that novel pathogens mayreactivated as a cause of infection after the transplantation. However, in the case of livertransplantation, the organ may be infected and the recipient may undergo the infection.The donor-derived parasite may not cause disease in the native host, but may increase invirulence with passage to a new host.Despite the fact that some of these parasitisms are endemic to specific areas, atpresent this should be not considered a specific risk in certain geographical areas, due tothe great quantity of emigrants. As migration around the world increases, the prevalenceof individuals infected with parasites increases also. Therefore, it is necessary to doprecise diagnostics in the donor and receiver, which is relevant to post-transplantmonitoring.The recipient should be treated with preoperative prophylaxis, and must be observedduring the transplant and post-transplant. An acute epidemiological and clinic historyfrom potential donors resident in areas in which the parasitic infections are endemic isimportant. The optimal immunosuppressive therapy must be checked. This work is fundamental for the success of organ transplants. In this chapter, wesome of these diseases. We describe the most useful methodology, as well as itsapplication for the precise diagnosis of the parasite in the laboratory. We also describetransmission mechanisms and the main factors of risk of each one of the parasitesinvolved. We consider it greatly important to show the actual diagnostic strategies thatcan be implemented to help programs in hospitals and institutions of health, in order toreduce the latent risk to the transplant patient. " 2009 by Nova Science Publishers, Inc. All rights reserved.
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