Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/40465
Title: Cytotoxic effect of curcumin on Giardia lamblia trophozoites
Author: Gallegos-Arreola, M.P.
Batista-Gonzalez, C.M.
Delgado-Lamas, J.L.
Figuera, L.E.
Puebla-Perez, A.M.
Arnaud-Lopez, L.
Peralta-Leal, V.
Ramirez-Jirano, L.J.
Zuniga-Gonzalez, G.M.
Issue Date: 2004
Abstract: We studied the role of cytochrome P4501A1 (CYP1A1 Val/Val) genotypes in the etiology of acute lymphoblastic leukemia (ALL) in adult Mexican patients. Distributions of CYP1A1 Val/Val genotypes in peripheral blood DNA samples from 136 healthy controls and 136 adult patients with ALL were evaluated. There was an increased frequency of the CYP1A1 Val/Val genotype among ALL patients, showing a significant association between this genotype and the risk of developing ALL. " 2004 Elsevier Inc. All rights reserved.",,,,,,"10.1016/j.bcmd.2004.07.002",,,"http://hdl.handle.net/20.500.12104/40465","http://www.scopus.com/inward/record.url?eid=2-s2.0-7544220274&partnerID=40&md5=a49483af5fe4c4af89fd227d318822f5",,,,,,"3",,"Blood Cells, Molecules, and Diseases",,"326
329",,"33",,"Scopus
WOS",,,,,,"Acute lymphoblastic leukemia; CYP1A1; Mexican population; Polymorphism",,,,,,"Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients",,"Article" "42237","123456789/35008",,"Piotrowicz-Cie lak, A.I., Dept. of Plant Physiol./Biotechnol., University of Warmia and Masuria, pl. dzki 3, 10-718 Olsztyn, Poland; Lopez, P.M.G., Departamento de Botanica y Zoologia, Universidad de Guadalajara Mexico, Carretera Gualadajara Nogales, Las Agujas Nextipac 6820003, Poland; Gulewicz, K., Inst. of Bioorganic Chemistry PAS, Noskowskiego 12, 61-704 Poznan, Poland",,"Piotrowicz-Cieslak, A.I.
Lopez, P.M.G.
Gulewicz, K.",,"2003",,"Ten to 16 ethanol-soluble carbohydrate components were identified in the seeds of six Mexican wild lupins. The analysed carbohydrates included: monosaccharides, disaccharides, cyclitols, galactosyl cyclitols and raffinose family oligosaccharides. Stachyose and sucrose were the main carbohydrate component in the Lupinus montanus, L. rotundiflorus, L. exaltatus, L. mexicanus and L. elegans seeds. Only trace quantities of verbascose were detected in Lupinus mexicanus seeds. The analysed seeds accumulated 38 to 78 mg/g d.m. carbohydrates. The raffinose family oligosaccharides constituted 41 to 85.2% of the identified carbohydrate component pool. The analysed Lupinus seeds contained 3 to 8 unidentified carbohydrate components.",,,,,,,,,"http://hdl.handle.net/20.500.12104/40458","http://www.scopus.com/inward/record.url?eid=2-s2.0-0038123072&partnerID=40&md5=bf84126e31e9bd9f78b9f7151cc8ea17",,,,,,"2",,"Acta Societatis Botanicorum Poloniae",,"109
114",,"72",,"Scopus
WOS",,,,,,"Carbohydrates; Cyclitols; Galactosyl cyclitols; Raffinose family oligosaccharides; Wild lupin seeds",,,,,,"Cyclitols, galactosyl cyclitols and raffinose family oligosaccharides in Mexican wild lupin seeds",,"Article" "42250","123456789/35008","Torres, Carlos Universidad de Guadalajara",,"Torres, Carlos Universidad de Guadalajara",,"2003",,,,,,,,,,"0188-8145",,"http://hdl.handle.net/20.500.12104/40471",,"Español",,,,"2",,"Acta comportamentalia",,"130-149",,"11",,"CLASE",,,,,,,,"Psicología experimental",,"Efectos de probabilidades complementarias y contrastadas de reforzamiento con y sin señalización en programas temporales",,,,"journalArticle", "42239","123456789/35008","Martínez, Alma Gabriela Universidad de Guadalajara",,"Martínez, Alma Gabriela Universidad de Guadalajara",,"2006",,,,,,,,,,"1657-9267",,"http://hdl.handle.net/20.500.12104/40460",,"Español",,,,"2",,"Universitas psychologica",,"361-370",,"5",,"CLASE",,,,,,,,"Psicología experimental",,"Efectos de modificar el contenido energético del agua sobre el peso corporal, consumo de agua, alimento y calorías en ratas",,,,"journalArticle", "42251","123456789/35008",,"Pérez-Arriaga, L., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco CP 44340, Mexico; Mendoza-Magaña, M.L., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco CP 44340, Mexico; Cortés-Zárate, R., Departamento de Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco CP 44340, Mexico; Corona-Rivera, A., Instituto de Genética, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco CP 44340, Mexico; Bobadilla-Morales, L., Instituto de Genética, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco CP 44340, Mexico; Troyo-Sanromán, R., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco CP 44340, Mexico; Ramírez-Herrera, M.A., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara, Jalisco CP 44340, Mexico",,"Perez-Arriaga, L.
Mendoza-Magana, M.L.
Cortes-Zarate, R.
Corona-Rivera, A.
Bobadilla-Morales, L.
Troyo-Sanroman, R.
Ramirez-Herrera, M.A.",,"2006",,"Giardia lamblia is one of the most important worldwide causes of intestinal infections produced by protozoa. Thus, the search for new alternative therapeutic approaches for this parasitic disease is very important. Common drugs used to control and eradicate this infection, frequently exhibit side effects that force patients to abandon treatment. The present work evaluates the anti-protozoan activity of curcumin, the main constituent of turmeric. Axenic G. lamblia (Portland 1 strain) cultures were exposed to different concentrations of curcumin. Its effects were evaluated on parasite growth, adhesion capacity and parasite morphology. We also evaluated the capacity of curcumin to induce an apoptosis-like effect. All curcumin concentrations inhibited trophozoite growth and adhesion in more than 50% in dose and time dependent manner. Morphological changes were described as protrusions formed under the cytoplasmic membrane, deformation due to swelling and cell agglutination. Curcumin induced apoptosis-like nuclear staining in dose and time dependent manner. In conclusion, curcumin exhibited a cytotoxic effect in G. lamblia inhibiting the parasite growth and adherent capacity, induced morphological alterations, provoked apoptosis-like changes. Future in vitro and in vivo experiments are endowed to elucidate the effect of curcumin in an experimental model of G. lamblia infection, analyze the involvement of ion channels in the swelling effect of curcumin during an apparent osmotic deregulation in G. lamblia trophozoites. This will lead to the proposal of the action mechanism of curcumin as well as the description of mechanism involved during the activation process for the apoptotic-like effect. " 2006 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/20.500.12104/40472
http://www.scopus.com/inward/record.url?eid=2-s2.0-33646876407&partnerID=40&md5=051b137a0a8d6b070faf59eb4aacad39
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16678115
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