Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/40303
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCastro-Garcia, F.P.
dc.contributor.authorCorral-Jara, K.F.
dc.contributor.authorEscobedo-Melendez, G.
dc.contributor.authorSandoval-Hernandez, M.A.
dc.contributor.authorRosenstein, Y.
dc.contributor.authorRoman, S.
dc.contributor.authorPanduro-Cerda, Arturo
dc.contributor.authorFierro, N.A.
dc.date.accessioned2015-09-15T17:35:41Z-
dc.date.available2015-09-15T17:35:41Z-
dc.date.issued2014
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84911964531&partnerID=40&md5=8b9243db54949c9cb178d28263161240
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24943111
dc.identifier.urihttp://hdl.handle.net/20.500.12104/40303-
dc.description.abstractSummary: Hepatitis A virus (HAV) infection is the major cause of acute liver failure in paediatric patients. The clinical spectrum of infection is variable, and liver injury is determined by altered hepatic enzyme function and bilirubin concentration. We recently reported differences in cytokine profiles between distinct HAV-induced clinical courses, and bilirubin has been recognized as a potential immune-modulator. However, how bilirubin may affect cytokine profiles underlying the variability in the course of infection has not been determined. Herein, we used a transcription factor (TF) binding site identification approach to retrospectively analyse cytokine expression in HAV-infected children and to predict the entire set of TFs associated with the expression of specific cytokine profiles. The results suggested that modulation of the activity of signal transducers and activators of transcription proteins (STATs) may play a central role during HAV infection. This led us to compare the degree of STAT phosphorylation in peripheral blood lymphoid cells (PBLCs) from paediatric patients with distinct levels of conjugated bilirubin (CB). Low CB levels in sera were associated with increased STAT-1 and STAT-5 phosphorylation. A positive correlation was observed between the serum interleukin-6 (IL-6) content and CB values, whereas higher levels of CB correlated with reduced serum IL-8 values and with a reduction in the proportion of PBLCs positive for STAT-5 phosphorylation. When CB was used to stimulate patients' PBLCs in vitro, the levels of IL-6 and tumour necrosis factor-? were increased. The data showed that bilirubin plays a role in STAT function and affects cytokine profile expression during HAV infection. � 2014 John Wiley & Sons Ltd.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyWOS
dc.relation.isreferencedbyMEDLINE
dc.titleConjugated bilirubin affects cytokine profiles in hepatitis A virus infection by modulating function of signal transducer and activator of transcription factors
dc.typeArticle
dc.identifier.doi10.1111/imm.12336
dc.relation.ispartofjournalImmunology
dc.relation.ispartofvolume143
dc.relation.ispartofissue4
dc.relation.ispartofpage578
dc.relation.ispartofpage587
dc.subject.keywordBilirubin; Hepatitis A virus; Signal transducer and activator of transcription protein; Transcription factors; Viral hepatitis
dc.contributor.affiliationCastro-Garc�a, F.P., Unidad de Inmunovirolog�a, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico; Corral-Jara, K.F., Unidad de Inmunovirolog�a, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico; Escobedo-Melendez, G., Servicio de Infecto-Pediatr�a, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico, Servicio de Hematolog�a y Oncolog�a Pedi�trica, Hospital Civil de Guadalajara Hospital Civil de Guadalajara Juan I. Menchaca.Guadalajara, Mexico; Sandoval-Hernandez, M.A., Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog�a, Universidad Nacional Aut�noma de M�xicoCuernavaca, Mexico; Rosenstein, Y., Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnolog�a, Universidad Nacional Aut�noma de M�xicoCuernavaca, Mexico; Roman, S., Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico, Servicio de Biolog�a Molecular, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico; Panduro, A., Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico, Servicio de Biolog�a Molecular, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico; Fierro, N.A., Unidad de Inmunovirolog�a, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraGuadalajara, Mexico, Servicio de Biolog�a Molecular, Hospital Civil de Guadalajara Fray Antonio AlcaldeGuadalajara, Mexico
dc.contributor.affiliationPanduro-Cerda, Arturo., Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud
dc.subject.headingIndex Medicus;Bilirubin/bl [Blood];Bilirubin/me [Metabolism];Case-Control Studies;Child;Child, Preschool;Cluster Analysis;Cytokines/bl [Blood];Cytokines/me [Metabolism];Female;Hepatitis A/im [Immunology];Hepatitis A/me [Metabolism];Hepatitis A virus/im [Immunology];Hepatitis A virus;Humans;Leukocytes, Mononuclear/me [Metabolism];Male;NF-kappa B/me [Metabolism];Patient Outcome Assessment;Phosphorylation;STAT Transcription Factors/me [Metabolism]
Appears in Collections:Producción científica UdeG

Files in This Item:
There are no files associated with this item.


Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.