Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/40078
Title: Circle detection on images using learning automata
Author: Aguilar-Chavez, E.A.
Gamez-Nava, J.I.
Lopez-Olivo, M.A.
Galvan-Melendres, S.
Corona-Sanchez, E.G.
Loaiza-Cardenas, C.A.
Celis, A.
Cardona-Munoz, E.G.
Gonzalez-Lopez, L.
Issue Date: 2009
Abstract: Objective. To evaluate the association between circulating leptin and bone mineral density (BMD) in patients with rheumatoid arthritis (RA). Methods. One-hundred thirty postmenopausal women with RA were assessed for body mass index (BMI), disease characteristics, history of drug use, rheumatoid factor, and erythrocyte sedimentation rate (ESR). BMD (g/cm 2) was determined in the hip and spine by DEXA. Serum leptin concentrations were measured by ELISA. Spearman's correlation coefficients (rho) were determined between BMD and leptin and other variables. A multiple regression analysis was used to adjust for confounders. Results. Patients' serum leptin levels varied widely (range 2-128 ng/ml). Thirty-three patients (25%) had osteoporosis. Higher levels of leptin correlated significantly with BMD in the lumbar spine (rho = 0.17, p = 0.04) and total hip (rho = 0.21, p = 0.01). The variables that were negatively correlated with BMD were age, duration of menopause, and ESR. After adjustment for confounders, leptin was no longer associated with BMD. In the multivariate model, factors that remained associated with BMD in the total hip were age (p = 0.021) and BMI (p = 0.003); and the factors that remained associated with BMD in the lumbar spine were BMI (p = 0.03) and ESR (p = 0.01). Conclusion. No relevant association was found between circulating leptin levels and BMD in patients with RA in this cross-sectional study. Followup studies are needed to evaluate whether abnormal leptin levels confer a risk for fractures due to osteoporosis. Copyright " 2009. All rights reserved.",,,,,,"10.3899/jrheum.080196",,,"http://hdl.handle.net/20.500.12104/40078","http://www.scopus.com/inward/record.url?eid=2-s2.0-65649139134&partnerID=40&md5=83ad3041713ea762d5c9c258be937d73",,,,,,"3",,"Journal of Rheumatology",,"512
516",,"36",,"Scopus
WOS",,,,,,"Bone mineral density; Leptin; Osteoporosis; Rheumatoid arthritis",,,,,,"Circulating leptin and bone mineral density in rheumatoid arthritis",,"Article" "41859","123456789/35008",,"García-Bañuelos, J., Inst. of Mol. Biol. Med./Gene Ther., CUCS, University of Guadalajara, Apdo Postal 2-123, Guadalajara, Jal 44281, Mexico; Siller-Lopez, F., Inst. of Mol. Biol. Med./Gene Ther., CUCS, University of Guadalajara, Apdo Postal 2-123, Guadalajara, Jal 44281, Mexico; Miranda, A., Inst. of Mol. Biol. Med./Gene Ther., CUCS, University of Guadalajara, Apdo Postal 2-123, Guadalajara, Jal 44281, Mexico; Aguilar, L.K., Inst. of Mol. Biol. Med./Gene Ther., CUCS, University of Guadalajara, Apdo Postal 2-123, Guadalajara, Jal 44281, Mexico; Aguilar-Cordova, E., Inst. of Mol. Biol. Med./Gene Ther., CUCS, University of Guadalajara, Apdo Postal 2-123, Guadalajara, Jal 44281, Mexico; Armendariz-Borunda, J., Inst. of Mol. Biol. Med./Gene Ther., CUCS, University of Guadalajara, Apdo Postal 2-123, Guadalajara, Jal 44281, Mexico",,"García-Banuelos, J.
Siller-Lopez, F.
Miranda, A.
Aguilar, L.K.
Aguilar-Cordova, E.
Armendariz-Borunda, J.",,"2002",,"Adenoviral vectors efficiently target normal liver cells; however, a clear-cut description of the safety boundaries for using adenovectors in hepatic cirrhosis has not been settled. With this in mind, we used a first-generation, replication-deficient adenoviral vector carrying the E. coli lacZ gene (Ad5?Gal) to monitor therapeutic range, biodistribution, toxicity and transduction efficiency in Wistar rats made cirrhotic by two different experimental approaches resembling alcoholic cirrhosis and biliary cirrhosis in humans. Further, we show proof of concept on fibrosis reversion by a 'therapeutic' Ad-vector (AdMMP8) carrying a gene coding for a collagen-degrading enzyme. Dose-response experiments with Ad5?Gal ranging from 1 108-3 1012 viral particles (vp) per rat (250 g), demonstrated that adenovirus-mediated gene transfer via iliac vein at 3 1011 vp/rat, resulted in an approximately 40% transduction in livers of rats made cirrhotic by chronic intoxication with carbon tetrachloride, compared with approximately 80% in control non-cirrhotic livers. In rats made cirrhotic by bile-duct obstruction only, 10% efficiency of transduction was observed. Biodistribution analyses showed that vector expression was detected primarily in liver and at a low level in spleen and kidney. Although there was an important increase in liver enzymes between the first 48 h after adenovirus injection in cirrhotic animals compared to non-transduced cirrhotic rats, this hepatic damage was resolved after 72-96 h. Then, the cDNA for neutrophil collagenase, also known as Matrix Metalloproteinase 8 (MMP8), was cloned in an Ad-vector and delivered to cirrhotic rat livers being able to reverse fibrosis in 44%. This study demonstrates the potential use of adenoviral vectors in safe transient gene therapy strategies for human liver cirrhosis.",,,,,,"10.1038/sj/gt/3301647",,,"http://hdl.handle.net/20.500.12104/40080","http://www.scopus.com/inward/record.url?eid=2-s2.0-0036190886&partnerID=40&md5=b376c70bfb8632148a898bbf832c49e9",,,,,,"2",,"Gene Therapy",,"127
134",,"9",,"Scopus
WOS",,,,,,"Cirrhosis; Fibrosis reversion; Gene transfer; Safety",,,,,,"Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion",,"Article" "41852","123456789/35008",,"Cuevas, E., Universidad de Guadalajara, CUCEI, Departamento de Ciencias Computacionales, Avenue Revolución 1500, Guadalajara, Jal, Mexico; Wario, F., Universidad de Guadalajara, CUCEI, Departamento de Ciencias Computacionales, Avenue Revolución 1500, Guadalajara, Jal, Mexico; Zaldivar, D., Universidad de Guadalajara, CUCEI, Departamento de Ciencias Computacionales, Avenue Revolución 1500, Guadalajara, Jal, Mexico; Pérez-Cisneros, M., Universidad de Guadalajara, CUCEI, Departamento de Ciencias Computacionales, Avenue Revolución 1500, Guadalajara, Jal, Mexico",,"Cuevas, E.
Wario, F.
Zaldivar, D.
Perez-Cisneros, M.",,"2012",,"Circle detection over digital images has received considerable attention from the computer vision community over the last few years devoting a tremendous amount of research seeking for an optimal detector. This article presents an algorithm for the automatic detection of circular shapes from complicated and noisy images with no consideration of conventional Hough transform (HT) principles. The proposed algorithm is based on Learning Automata (LA) which is a probabilistic optimisation method that explores an unknown random environment by progressively improving the performance via a reinforcement signal (objective function). The approach uses the encoding of three non-collinear points as a candidate circle over the edge image. A reinforcement signal (matching function) indicates if such candidate circles are actually present in the edge map. Guided by the values of such reinforcement signal, the probability set of the encoded candidate circles is modified through the LA algorithm so that they can fit to the actual circles on the edge map. Experimental results over several complex synthetic and natural images have validated the efficiency of the proposed technique regarding accuracy, speed and robustness. " 2012 The Institution of Engineering and Technology.
URI: http://hdl.handle.net/20.500.12104/40073
http://www.scopus.com/inward/record.url?eid=2-s2.0-84858742926&partnerID=40&md5=6d9d45088a29765a990d7668e584913b
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