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Title: Circulating E-selectin and tumor necrosis factor-? in extraarticular involvement and joint disease activity in rheumatoid arthritis
Author: Corona-Sanchez, E.G.
Gonzalez-Lopez, L.
Munoz-Valle, J.F.
Vazquez-Del Mercado, M.
Lopez-Olivo, M.A.
Aguilar-Chavez, E.A.
Salazar-Paramo, M.
Loaiza-Cardenas, C.
Oregon-Romero, E.
Navarro-Hernandez, R.E.
Gamez-Nava, J.I.
Issue Date: 2009
Abstract: In this cross-sectional study, we assessed the relationship between circulating TNF-? and E-selectin (sE-selectin) with extraarticular involvement and severity of joint disease in RA. We compared 56 patients who had RA and extraarticular involvement (ExRA) with a group of 84 patients with only articular involvement (non-ExRA). ExRA had higher circulating TNF-? than non-ExRA (32 � 9 vs. 28 � 6 pg/mL, P = 0.002). sE-selectin levels did not differ between both groups. sE-selectin correlated with tender joint count (rho = 0.19, P = 0.03), morning stiffness (rho = 0.19, P = 0.03), severity of pain (rho = 0.21, P = 0.02), disease activity (assessed by the patient) (rho = 0.21, P = 0.02), HAQ-DI (rho = 0.29, P = 0.004), and rheumatoid factor titers (rho = 0.31, P = <0.001). Circulating TNF-? had no correlation with sE-selectin or disease activity. We concluded that sE-selectin correlated with severity of joint disease, further follow-up studies should evaluate if sE-selectin is useful as prognosis marker for progression of articular damage. � 2008 Springer-Verlag.
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