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Title: Cervical human papillomavirus infection in Mexican women with systemic lupus erythematosus or rheumatoid arthritis
Author: Rojo-Contreras, W.
Olivas-Flores, E.M.
Gamez-Nava, J.I.
Montoya-Fuentes, H.
Trujillo-Hernandez, B.
Trujillo, X.
Suarez-Rincon, A.E.
Baltazar-Rodriguez, L.M.
Sanchez-Hernandez, J.
Ramirez-Flores, M.
Vazquez-Salcedo, J.
Rojo-Contreras, J.
Morales-Romero, J.
Gonzalez-Lopez, L.
Issue Date: 2012
Abstract: Cervical human papillomavirus (HPV+) infection is associated with an increased risk of cervical dysplasia. Although the frequency of HPV+ in systemic lupus erythematosus (SLE) has been investigated in some races its prevalence in Hispanic women is still unknown. This cross-sectional study evaluated the prevalence of cervical HPV+ in Mexican women with SLE (n = 34) or rheumatoid arthritis (RA) (n = 43) and in healthy controls (n = 146). These women were interviewed about risk factors for sexually transmitted infections and cervical cytology analysis was performed. HPV+ viral types were identified using PCR: HPV+ was observed in 14.7% of SLE, 27.9% of RA and 30.8% of controls. High-risk HPV types were observed in 11.7% of women with SLE, 27.9% of women with RA, and in 26% of the controls. High-risk viral types 58, 35 and 18 were the most frequently identified in SLE. Two women with SLE had a high-grade squamous intraepithelial lesion and one had cervical cancer. An association was observed between methotrexate utilization, longer duration of therapy with prednisone, and HPV+ in RA or SLE. Thus, there is a high prevalence of cervical HPV infection in Mexican women with SLE or RA, and physicians must be vigilant in preventing the development of cervical dysplasia. Zapotitlán 2011 The Author(s).
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