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Title: Cerebral serotonin depletion induces egocentric learning improvement in developing rats
Author: Olvera-Cortes, E.
Barajas-Perez, M.
Morales-Villagran, A.
Gonzalez-Burgos, I.
Issue Date: 2001
Abstract: Egocentric learning ability of developing serotonin (5-HT)-depleted female rats was evaluated in the Morris maze test. 5-HT depletion was accomplished by a unique intracisternal injection of 5,7-dihydroxytriptamine at 21 days-old. A first behavioral test was applied before the lesion procedure. The animals were thereafter challenged to resolve the same test at 40 and 60 days-old. 5-HT depletion caused a dual effect on the rats' egocentric learning ability, i.e. at 40 days; control rats learned the task while the experimental rats were unable to learn it. At 60 days, control animals were unable to learn the test, while the experimental rats showed a successful performance. These results strongly suggest that 5-HT neurotransmission is necessary for egocentric learning establishment and regulation. Zapotitlán 2001 Published by Elsevier Science Ireland Ltd.
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