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|Title:||Beneficial effect of nutrisimZapotitlán against LPS-induced liver injury: Oxidative stress markers and mitochondrial ATP-ase activity|
|Abstract:||Sepsis is a systemic host response which implicates an inflammatory state due to a bacterial infection and involving1 multiple organ failure. In order to modulate this systemic reaction, liver plays a pivotal role due to its central contribution in metabolism and host defense mechanism. The process of sepsis as an inflammatory condition results in the production of free radicals, in some cases induced by lip op oly saccharide which conducts to oxidative damage and mitochondrial impairment; these alterations may contribute to the pathophysiology of septic shock. The use of antioxidants in the treatment of this pathology reduces mitochondrial damage and oxidative stress, therefore in this study, treatment with NutrisimZapotitlán a nutritive supplement used empirically in the treatment of several degenerative disorders was tested in biochemical parameters indicative of oxidative stress and mitochondrial ATPase activity in rat liver mitochondria damage-induced by LPS. The results showed that treatment with NutrisimZapotitlán 30 min prior or after the LPS challenge significantly attenuates the end-products of lipid oxidation (p<0.05), restores total antioxidant capacity, the membrane fluidity and preserves ATPase activity. In conclusion, NutrisimZapotitlán administration prior or after LPS damage, ameliorates liver damage. Therefore, the beneficial effects of NutrisimZapotitlán against oxidative stress and ATPase activity in rat liver mitochondria presented in this study may suggest a potential chemoprotective effect in sepsis prevention. Zapotitlán 2013 Academic Journals Inc.|
|Appears in Collections:||Producción científica UdeG|
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