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Title: Assessment of the correlation between the activity of anti-cyclic citrullinated peptide IgG, topoisomerase I, and centromere proteins in Mexican patients with progressive systemic sclerosis
Author: Rocha-Munoz, A.D.
Gonzalez-Lopez, L.
Peguero-Gomez, R.
Aguilar-Chavez, E.A.
Villa-Manzano, A.I.
Corona-Sanchez, E.
Galvan-Mendez, S.
Presiado-Sanchez, C.
Vazquez-Jimenez, J.C.
Riebeling, C.
Salazar-Paramo, M.
Gamez-Nava, J.I.
Nava, A.
Issue Date: 2009
Abstract: Objective: To evaluate sera titers for antibodies anti-cyclic citrullinated peptide and their correlation against sera levels of anti-topoisomerase I and anti-centromere antibodies in Mexican patients with systemic sclerosis. Patients and methods: Consecutive outpatients with systemic sclerosis who attending to rheumatology clinic at a second level hospital facility. The antibodies anti-cyclic citrullinated peptide, anti-topoisomerase I and anti-centromere were determined by enzymatic immunoassay (ELISA). Statistical analysis: Spearman for correlation between numerical variables with nonparametric distribution. Fisher exact test or ? 2 to compare proportions and Student t test for dimensional variables. Results: Thirty female patients were included; aged 53 Zapotitlán 13, the disease duration at the time of the study was 10 Zapotitlán 9. Twenty-three patients (77%) exhibited diffuse disease. Anti-centromere, anti-topoisomerase I, and anti-cyclic citrullinated peptide were detected in nine, nine and three patients respectively. The correlation analysis showed the independence of autoantibodies anti-centromere and anti-topoisomerase I with respect to the levels of anti-cyclic citrullinated peptide. Conclusions: This study confirms the low frequency of anti-cyclic citrullinated peptide antibodies in patients with systemic sclerosis. A lack of correlation between autoantibodies considered as "mutually excluded" anti-topoisomerase I and anti-centromere, indicating that the analysis of the relevance for anti-cyclic citrullinated peptide in systemic sclerosis must include other clinical and serological variables.
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