Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/39590
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDuenas Jimenez, J.M.
dc.contributor.authorCandanedo Arellano, A.
dc.contributor.authorSanterre, A.
dc.contributor.authorOrozco Suarez, S.
dc.contributor.authorSandoval Sanchez, H.
dc.contributor.authorFeria Romero, I.
dc.contributor.authorLopez-Elizalde, R.
dc.contributor.authorAlonso Venegas, M.
dc.contributor.authorNetel, B.
dc.contributor.authorde la Torre Valdovinos, B.
dc.contributor.authorDuenas Jimenez, S.H.
dc.date.accessioned2015-09-15T17:21:56Z-
dc.date.available2015-09-15T17:21:56Z-
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/20.500.12104/39590-
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84903807611&partnerID=40&md5=9c41927bebfdbfff256c291b4e545753
dc.description.abstractEstrogens are oncogenic hormones at a high level in breast, prostate, endometrial and lung cancer. Estrogens are synthesized by aromatase which has been used as a biomarker both in breast and lung cancer. Estrogen biological activities are executed by their classic receptors (ER? and ER?). ER? has been described as a cancer promoter and ER?, as a possible tumor suppressor. Both receptors are present at low levels in primary multiforme glioblastoma (GBM). The GBM frequency is 50 % higher in men than in women. The GBM patient survival period ranges from 7 to 18 months. The purpose of this pilot study was to evaluate aromatase and estrogen receptor expression, as well as 17Zapotitlán-estradiol concentration in astrocytoma patients biopsies to obtain a prognosis biomarker for these patients. We analyzed 36 biopsies of astrocytoma patients with a different grade (I-IV) of malignity. Aromatase and estrogen receptor mRNA expression were analyzed by semiquantitative RT-PCR, and the E2 levels, by ELISA. E2 concentration was higher in GBM, compared to grade II or III astrocytomas. The number of cells immunoreactive to aromatase and estrogen receptors decreased as the grade of tumor malignity increased. Aromatase mRNA expression was present in all biopsies, regardless of malignity grade or patient age or gender. The highest expression of aromatase mRNA in GBM patients was associated to the worst survival prognostic (6.28 months). In contrast lowest expression of ER? mRNA in astrocytoma patients had a worst prognosis. In conclusion, aromatase and ER? expression could be used as prognosis biomarkers for astrocytoma patients. Zapotitlán 2014 Springer Science+Business Media New York.
dc.relation.isreferencedbyScopus
dc.titleAromatase and estrogen receptor alpha mRNA expression as prognostic biomarkers in patients with astrocytomas
dc.typeArticle in Press
dc.identifier.doi10.1007/s11060-014-1509-z
dc.relation.ispartofjournalJournal of Neuro-Oncology
dc.subject.keyword17Zapotitlán-estradiol; Aromatase mRNA; Astrocytoma; Estrogen receptor; Survival time
dc.contributor.affiliationDueñas Jiménez, J.M., Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Candanedo Arellano, A., Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Santerre, A., Centro Universitario de Ciencias Biológicas y Agropecuarias, Guadalajara, Mexico; Orozco Suárez, S., Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades CMN, Siglo XXI, IMSS, Mexico, Distrito Federal, Mexico; Sandoval Sánchez, H., Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico; Feria Romero, I., Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades CMN, Siglo XXI, IMSS, Mexico, Distrito Federal, Mexico; López-Elizalde, R., Hospital Civil Juan I. Menchaca, Guadalajara, Jalisco, Mexico; Alonso Venegas, M., Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, Distrito Federal, Mexico; Netel, B., Servicio de Neurocirugía Hospital de Especialidades CMN Siglo XXI, IMSS, Mexico, Distrito Federal, Mexico; de la Torre Valdovinos, B., Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Dueñas Jiménez, S.H., Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
Appears in Collections:Producción científica UdeG

Files in This Item:
There are no files associated with this item.


Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.