Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/39520
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dc.contributor.authorGonzalez-Lopez, L.
dc.contributor.authorRocha-Munoz, A.D.
dc.contributor.authorPonce-Guarneros, M.
dc.contributor.authorFlores-Chavez, A.
dc.contributor.authorSalazar-Paramo, M.
dc.contributor.authorNava, A.
dc.contributor.authorCardona-Munoz, E.G.
dc.contributor.authorFajardo-Robledo, N.S.
dc.contributor.authorZavaleta-Muniz, S.A.
dc.contributor.authorGarcía-Cobian, T.
dc.contributor.authorGamez-Nava, J.I.
dc.date.accessioned2015-09-15T17:20:38Z-
dc.date.available2015-09-15T17:20:38Z-
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/20.500.12104/39520-
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84900307881&partnerID=40&md5=ea8ddea610dc47159482ce14a19782ce
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=24804270
dc.description.abstractWe evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There was no association of anti-CCP and anti-MCV levels with the presence of ExRA as total group (P = 0.40 and P = 0.91, resp.). Making an analysis of individual manifestations, rheumatoid nodules were associated with positivity for rheumatoid factor (RF); (P = 0.01), anti-CCP (P = 0.048), and anti-MCV (P = 0.02). Instead, RF, anti-CCP, or anti-MCV were not associated with SS, chronic anemia, or peripheral neuropathy. Levels of anti-CCP correlated with the score of the Health Assessment Questionnaire-Disability Index (HAQ-Di) (r = 0.154, P = 0.03), erythrocyte sedimentation rate (ESR); (r = 0.155, P = 0.03), and RF (P = 0.254, P < 0.001), whereas anti-MCV titres only correlated with RF (r = 0.169, P = 0.02). On adjusted analysis, ExRA was associated with longer age (P = 0.015), longer disease duration (P = 0.007), higher DAS-28 score (P = 0.002), and higher HAQ-DI score (P = 0.007), but serum levels of anti-CCP and anti-MCV were not associated. These findings show the need to strengthen the evaluation of the pathogenic mechanisms implied in each specific ExRA manifestation. Zapotitlán 2014 Laura Gonzalez-Lopez et al.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyWOS
dc.relation.isreferencedbyMEDLINE
dc.titleAnti-cyclic citrullinated peptide (Anti-CCP) and anti-mutated citrullinated vimentin (Anti-MCV) relation with extra-articular manifestations in rheumatoid arthritis
dc.typeArticle
dc.identifier.doi10.1155/2014/536050
dc.relation.ispartofjournalJournal of Immunology Research
dc.relation.ispartofvolume2014
dc.contributor.affiliationGonzalez-Lopez, L., Department of Internal Medicine - Rheumatology, Hospital General Regional 110, IMSS, Avenida Salto Del Agua 2192, Colonia Jardines Del Country, 44710 Guadalajara, Jal, Mexico; Rocha-Muñoz, A.D., Postdoctoral Program of the National Council of Science and Technology (CONACYT), 03940 Mexico City DF, Mexico; Ponce-Guarneros, M., Department of Internal Medicine - Rheumatology, Hospital General Regional 110, IMSS, Avenida Salto Del Agua 2192, Colonia Jardines Del Country, 44710 Guadalajara, Jal, Mexico, Postgraduate Programs of Pharmacology and Public Health Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, 44340 Guadalajara, Jal Udg.mx, Mexico; Flores-Chavez, A., Clinical Epidemiology Research Unit, UMAE, Specialties Hosp., W. Med. Ctr., Mex. Inst. for Social Security , 44340 Guadalajara, Jal Imss.gob.mx, Mexico; Salazar-Paramo, M., Physiology Department, CUCS, University of Guadalajara Research Division, UMAE, CMNO, IMSS, 44340 Guadalajara, Jal Udg.mx, Mexico; Nava, A., Clinical Epidemiology Research Unit, UMAE, Specialties Hosp., W. Med. Ctr., Mex. Inst. for Social Security , 44340 Guadalajara, Jal Imss.gob.mx, Mexico; Cardona-Muñoz, E.G., Department of Physiology, CUCS, University of Guadalajara, 44340 Guadalajara, Jal Udg.mx, Mexico; Fajardo-Robledo, N.S., Clinical Epidemiology Research Unit, UMAE, Specialties Hosp., W. Med. Ctr., Mex. Inst. for Social Security , 44340 Guadalajara, Jal Imss.gob.mx, Mexico; Zavaleta-Muñiz, S.A., Postgraduate Program of Biomedical Sciences (Immunology), CUCS, University of Guadalajara, 44340 Guadalajara, Jal Udg.mx, Mexico; García-Cobian, T., Postgraduate Programs of Pharmacology and Public Health Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, 44340 Guadalajara, Jal Udg.mx, Mexico; Gamez-Nava, J.I., Clinical Epidemiology Research Unit, UMAE, Specialties Hosp., W. Med. Ctr., Mex. Inst. for Social Security , 44340 Guadalajara, Jal Imss.gob.mx, Mexico
dc.subject.headingIndex Medicus;Adult;Aged;Arthritis, Rheumatoid/co [Complications];Arthritis, Rheumatoid/di [Diagnosis];Arthritis, Rheumatoid/im [Immunology];Autoantibodies/bl [Blood];Autoantibodies/im [Immunology];Female;Humans;Male;Middle Aged;Peptides, Cyclic/im [Immunology];Risk Factors;Severity of Illness Index;Vimentin/im [Immunology]
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