Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/39329
Title: Alpha-thalassemia in a selected population of Mexico
Author: Casas-Castaneda, M.
Hernandez-Lugo, I.
Torres, O.
Barajas, H.
Cibrian, S.
Zamudio, G.
Villalobos-Arambula, A.R.
Hermosillo-Banuelos, R.M.
Perea, F.J.
Ibarra, B.
Issue Date: 1998
Abstract: Objective. To identify by molecular biology the alleles of ?-Thal in selected hospital populations. Methods. Eighteen propositi with hematological and biochemical data suggestive of ?-thalassemia, selected from 356 patients of four hospitals in two cities with probable hemoglobinopathy were investigated for six common ?-Thal alleles. Molecular studies were done by PCR and digestion with specific restriction enzymes. Results. The ? 3.7 allele was identified in two cases and the family study revealed the same allele in the mother; HbS heterozigocity was also detected in one of them. An analysis with Apa I demonstrated a class I deletion in both patients. The present study showed 2/356 (0.6%) of ? 3.71 carriers which is a low frequency as compared with other countries. As no other common ?-thalassemia alleles were found, we suspect that ?-Thal in Mexico is as heterogeneous at a molecular level as ?-Thal.
URI: http://hdl.handle.net/20.500.12104/39329
http://www.scopus.com/inward/record.url?eid=2-s2.0-17644428484&partnerID=40&md5=79616c1a231d61b2cdf7915663aafdc0
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