Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/39313
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dc.contributor.authorRoman, S.
dc.contributor.authorZepeda-Carrillo, E.A.
dc.contributor.authorMoreno-Luna, L.E.
dc.contributor.authorPanduro-Cerda, Arturo
dc.date.accessioned2015-09-15T17:16:47Z-
dc.date.available2015-09-15T17:16:47Z-
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/20.500.12104/39313-
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84888610224&partnerID=40&md5=8e23531ecd574a1f1e00f4a3f4893996
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=24307790
dc.description.abstractAlcoholism and cirrhosis, which are two of the most serious health problems worldwide, have a broad spectrum of clinical outcomes. Both diseases are influenced by genetic susceptibility and cultural traits that differ globally but are specific for each population. In contrast to other regions around the world, Mexicans present the highest drinking score and a high mortality rate for alcoholic liver disease with an intermediate category level of per capita alcohol consumption. Mexico has a unique history of alcohol consumption that is linked to profound anthropological and social aspects. The Mexican population has an admixture genome inherited from different races, Caucasian, Amerindian and African, with a heterogeneous distribution within the country. Thus, genes related to alcohol addiction, such as dopamine receptor D2 in the brain, or liver alcoholmetabolizing enzymes, such as alcohol dehydrogenase class I polypeptide B, cytochrome P450 2E1 and aldehyde dehydrogenase class 2, may vary from one individual to another. Furthermore, they may be inherited as risk or non-risk haplogroups that confer susceptibility or resistance either to alcohol addiction or abusive alcohol consumption and possibly liver disease. Thus, in this era of genomics, personalized medicine will benefit patients if it is directed according to individual or population-based data. Additional association studies will be required to establish novel strategies for the prevention, care and treatment of liver disease in Mexico and worldwide. Zapotitlán 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyMEDLINE
dc.relation.isreferencedbyWOS
dc.titleAlcoholism and liver disease in Mexico: Genetic and environmental factors
dc.typeReview
dc.identifier.doi10.3748/wjg.v19.i44.7972
dc.relation.ispartofjournalWorld Journal of Gastroenterology
dc.relation.ispartofvolume19
dc.relation.ispartofissue44
dc.relation.ispartofpage7972
dc.relation.ispartofpage7982
dc.subject.keywordAlcohol; Alcohol abuse; Alcohol addiction; Alcohol dependence; Alcoholic liver cirrhosis; Alcoholism; Anthropology; Genes / Index Medicus;Alcohol Drinking/ae [Adverse Effects];Alcohol Drinking/eh [Ethnology];Alcohol Drinking/ge [Genetics];Alcohol Drinking/mo [Mortality];Alcoholic Beverages;Alcoholism/eh [Ethnology];Alcoholism/ge [Genetics];Alcoholism/mo [Mortality];Cultural Characteristics;Gene-Environment Interaction;Genetic Predisposition to Disease;Heredity;Humans;Liver Diseases, Alcoholic/eh [Ethnology];Liver Diseases, Alcoholic/ge [Genetics];Liver Diseases, Alcoholic/mo [Mortality];Mexico/ep [Epidemiology];Pedigree;Prognosis;Risk Factors;Social Behavior
dc.contributor.affiliationRoman, S., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, 'Fray Antonio Alcalde' and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico; Zepeda-Carrillo, E.A., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, 'Fray Antonio Alcalde' and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico, Universidad Autónoma de Nayarit and Hospital Civil Tepic 'Antonio González Guevara', Tepic, Nayarit 63000, Mexico; Moreno-Luna, L.E., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, 'Fray Antonio Alcalde' and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico; Panduro, A., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, 'Fray Antonio Alcalde' and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico
dc.contributor.affiliationPanduro-Cerda, Arturo., Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud
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