Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/39212
Title: Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Mexico: Overall results of a 7-year project
Author: Sanchez-Ramirez, C.A.
Larrosa-Haro, A.
Flores-Martinez, S.
Sanchez-Corona, J.
Villa-Gomez, A.
Macias-Rosales, R.
Issue Date: 2007
Abstract: Objectives: To describe the clinical picture and outcome, and to assess the etiological factors of acute and recurrent pancreatitis in children. Methods: Thirty-six (65.5%) patients with acute and 19 (34.5%) with recurrent pancreatitis were studied. Mean age was 126 (41.3 SD) months; 27 (49.1%) were females. Setting: a pediatric referral hospital. Period: 2000-2005. Design: cross-sectional. Variables: clinical and laboratory data and etiological factors. Statistics: ?2-test, Fisher test, OR, confidence interval, Student t-test and Mann-Whitney U-test. Results: The most frequent symptom in acute and recurrent pancreatitis was abdominal pain, followed by vomiting and ileus. The severity of pancreatitis and complications were similar in both groups. Biliary stones, family history of pancreatitis, drug ingestion and hypercalcemia occurred in both groups. Abdominal trauma and acute hepatitis A occurred in patients with acute pancreatitis; triglyceride >5.65 mmol/L, pancreas divisum and ?F508 mutation occurred in patients with recurrent pancreatitis. No difference was observed when frequency factors between study groups were compared. Conclusions: The clinical picture and etiological factors were similar in both groups. Since one out of every three children with acute pancreatitis in this series presented recurrences, it was not considered to be a 'benign disease'. Fifteen different etiological factors were identified in two-thirds of the cases. " 2007 The Author(s).",,,,,,"10.1111/j.1651-2227.2007.00225.x",,,"http://hdl.handle.net/20.500.12104/39212","http://www.scopus.com/inward/record.url?eid=2-s2.0-33947495090&partnerID=40&md5=6d8acec44d11519da8fc0d2415207fa8
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17306005",,,,,,"4",,"Acta Paediatrica, International Journal of Paediatrics",,"534
537",,"96",,"Scopus
WOS
MEDLINE",,,,,,"?F508 mutation; Acute pancreatitis; Etiological factors; Recurrent pancreatitis / Index Medicus;Adolescent;Child;Child, Preschool;Cross-Sectional Studies;Cystic Fibrosis Transmembrane Conductance Regulator/ge [Genetics];Female;Hospitalization;Humans;Male;Mutation/ge [Genetics];Outcome Assessment (Health Care);Pancreatitis/et [Etiology];Recurrence;Risk Factors",,,,,,"Acute and recurrent pancreatitis in children: Etiological factors",,"Article" "40992","123456789/35008",,"Chiquete, E., Departamento de Neurología y Psiquiatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Ciudad de México. C.P. 14000, Mexico, Departamento de Neurología, Hospital General de Zona Valentín Gómez Farías, ISSSTE. Zapopan; México; Ruiz-Sandoval, J.L., Servicio de Neurología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico, Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Departamento de Neurología, Hospital General de Zona Valentín Gómez Farías, ISSSTE. Zapopan; México; Murillo-Bonilla, L.M., Departamento de Neurología, Facultad de Medicina, Universidad Autónoma de Guadalajara, Zapopan, Mexico, Departamento de Neurología, Hospital General de Zona Valentín Gómez Farías, ISSSTE. Zapopan; México; Arauz, A., Clínica de Enfermedad Cerebrovascular, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, Mexico, Departamento de Neurología, Hospital General de Zona Valentín Gómez Farías, ISSSTE. Zapopan; México; Villarreal-Careaga, J., Departamento de Neurología, Hospital General de Culiacán, Culiacán, Mexico, Departamento de Neurología, Hospital General de Zona Valentín Gómez Farías, ISSSTE. Zapopan; México; León-Jiménez, C., Departamento de Neurología y Psiquiatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Ciudad de México. C.P. 14000, Mexico, Departamento de Neurología, Hospital General de Zona Valentín Gómez Farías, ISSSTE. Zapopan; México; Barinagarrementería, F., Departamento de Neurología, Hospital General de Zona Valentín Gómez Farías, ISSSTE. Zapopan; México, Departamento de Neurología, Hospital Ángeles de Querétaro, Querétaro, Mexico; Cantú-Brito, C., Departamento de Neurología y Psiquiatría, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Ciudad de México. C.P. 14000, Mexico, Departamento de Neurología, Hospital General de Zona Valentín Gómez Farías, ISSSTE. Zapopan; México",,"Chiquete, E.
Ruiz-Sandoval, J.L.
Murillo-Bonilla, L.M.
Arauz, A.
Villarreal-Careaga, J.
Leon-Jimenez, C.
Barinagarrementeria, F.
Cantu-Brito, C.",,"2012",,"Introduction: Cerebrovascular disease (CVD) mortality in Mexico has shown a growing pattern in recent years. It is not known whether data obtained in the important multicenter CVD Mexican registries adequately represent all the hospital units of the health system. Objective: To describe the frequency of acute CVD subtypes and shortterm outcome in discharge registries from public institutions of the Mexican health system, during the year 2010. Methods: We consulted the Mexican public health system database of hospital discharges corresponding to the year 2010 (Secretaría de Salud, IMSS, IMSS Oportunidades, ISSSTE, PEMEX, SEMAR y SEDENA). CVD registries were identified with the International Classification of Diseases 10th revision codes (ICD-10). Specified CVD was defined as the existence of ICD-10 codes describing precise CVD subtypes. Results: In 2010, a total of 5,314,132 hospital discharges were registered in the Mexican public health system. Of them, 46,247 (0.9%) were acute CVD including: acute ischemic stroke (AIS) 20,298 (43.9%), intracerebral hemorrhage (ICH) 6,005 (13.0%), subarachnoid hemorrhage 2,655 (5.7%), cerebral venous thrombosis (CVT) 194 (0.4%) and non-specified CVD 17,095 (37.0%). Among specified CVD discharges (n=29,152), 69.6% corresponded to AIS, 20.6% to ICH, 9.1% to SAH and 0.7% to CVT. The global 30-day case fatality rate was 17.1% (18.8% among specified subtypes); higher for ICH (33.6%), followed by SAH (29.3%) and AIS (13.9%) (p < 0.001). Conclusions: The relative frequency of acute CVD subtypes by the year 2010 was similar to that of the previous Mexican multicenter registries. Short-term mortality is higher in hemorrhagic forms of CVD, as compared with ischemic stroke.",,,,,,,,,"http://hdl.handle.net/20.500.12104/39213","http://www.scopus.com/inward/record.url?eid=2-s2.0-84871379290&partnerID=40&md5=bbe1e21c7e5e06a7499da9540e0f1256",,,,,,"5",,"Revista Mexicana de Neurociencia",,"252
258",,"13",,"Scopus",,,,,,"Cerebrovascular disease; Epidemiology; Mortality; Outcome; Stroke",,,,,,"Acute cerebrovascular disease discharges from public institutions of the Mexican Ministry of Health: An analysis on 5.3 millions of hospitalizations in 2010 [Egresos por enfermedad vascular cerebral aguda en instituciones públicas del sector salud de México: Un análisis de 5.3 millones de hospitalizaciones en 2010]",,"Article" "40993","123456789/35008",,"Jaime-Andrade, J., Zoológico Guadalajara, Departamento de Patología Animal del Cuba, Universidad de Guadalajara, Jalisco, México.; Avila-Figueroa, D., Zoológico Guadalajara, Departamento de Patología Animal del Cuba, Universidad de Guadalajara, Jalisco, México.; Lozano-Kasten, F.J., Zoológico Guadalajara, Departamento de Patología Animal del Cuba, Universidad de Guadalajara, Jalisco, México.; Hernández-Gutiérrez, R.J., Zoológico Guadalajara, Departamento de Patología Animal del Cuba, Universidad de Guadalajara, Jalisco, México.; Magallán-Gastélum, E., Zoológico Guadalajara, Departamento de Patología Animal del Cuba, Universidad de Guadalajara, Jalisco, México.; Kasten-Monges, M.J., Zoológico Guadalajara, Departamento de Patología Animal del Cuba, Universidad de Guadalajara, Jalisco, México.; Lopes, E.R., Zoológico Guadalajara, Departamento de Patología Animal del Cuba, Universidad de Guadalajara, Jalisco, México.",,"Jaime-Andrade, J.
Avila-Figueroa, D.
Lozano-Kasten, F.J.
Hernandez-Gutierrez, R.J.
Magallon-Gastelum, E.
Kasten-Monges, M.J.
Lopes, E.R.",,"1997",,"We report a 24-year-old female polar bear (Ursus maritimus) who contracted Chagas' infection at the Guadalajara Zoo, in Jalisco, México, and died of acute Chagas' carditis 15 days later. The histopathological findings are described, as well as the presence of triatomids (Triatoma longipennis Usinger) infected with Trypanosoma cruzi collected within 5 meters from the place where the animal lived in the city of Guadalajara.",,,,,,,,,"http://hdl.handle.net/20.500.12104/39214","http://www.scopus.com/inward/record.url?eid=2-s2.0-0031178358&partnerID=40&md5=f1bc88574977de0c2b4cad3e8946e09d
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=9219444",,,,,,"4",,"Revista da Sociedade Brasileira de Medicina Tropical",,"337
340",,"30",,"Scopus
MEDLINE",,,,"Index Medicus;Animals;Animals, Zoo/ps [Parasitology];Animals, Zoo;Chagas Cardiomyopathy/ps [Parasitology];Chagas Cardiomyopathy/pa [Pathology];Chagas Cardiomyopathy/ve [Veterinary];Female;Heart/ps [Parasitology];Insect Vectors/ps [Parasitology];Mexico;Myocardium/pa [Pathology];Triatoma/ps [Parasitology];Trypanosoma cruzi/ip [Isolation & Purification];Ursidae/ps [Parasitology];Ursidae",,,,,,,,"Acute Chagas' cardiopathy in a polar bear (Ursus maritimus) in Guadalajara, Mexico.",,"Review" "44699","123456789/35008",,"Vaca, G., División de Genética, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico; Arambula, E., División de Genética, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico, Doctorado en Genética Humana, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Esparza, A., Departamento de Hematologia, Hospital de Pediatria, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico",,"Vaca, G.
Arambula, E.
Esparza, A.",,"2002",,"Several years ago, a project aiming to determine (i) the molecular basis of G-6-PD deficiency, (ii) the distribution of four different mutant alleles previously detected, and (iii) the whole of polymorphic alleles that account for the overall prevalence of G-6-PD deficiency in Mexico was implemented. Nearly 5000 individuals - from the general population and patients with hemolytic anemia - belonging to at least 14 States were screened for G-6-PD deficiency. Seventy-six G-6-PD-deficient subjects were detected and the prevalence of G-6-PD deficiency in 4777 individuals from the general population was 0.71%. Screening for both mutations associated with enzyme deficiency and silent polymorphisms at the G-6-PD gene was performed in the enzyme-deficient individuals by PCR-SSCP combined with restriction enzyme analysis; the silent polymorphisms as well as the nondeficient variant G-6-PD A376G were also investigated in 366 G-6-PD normal individuals from the general population. In 88% of the enzyme-deficient individuals it was possible to define the mutation responsible and the type G-6-PD A - variants were the more common in both individuals from the general population and patients with hemolytic anemia. G-6-PD deficiency is heterogeneous at the DNA level in Mexico and up to date 10 different variants - 8 in the present project and 2 previously - have been observed: G-6-PD A-202A/376G, G-6-PD A-376G/968C, G-6-PD Santamaria376G/542T, G-6-PD Vanua Lava383C, G-6-PD Tsukuidel561-563, G-6-PD "Mexico City"680A, G-6-PD Seattle844C, G-6PD Guadalajara1159T,G-6-PD Nashville1178A, and G-6-PD Union1360T. The G-6-PD A- variants have a relatively homogeneous distribution and along with G-6-PD Santamaria376G/542T, they account for 82% of the overall prevalence of G-6-PD deficiency in Mexico; all other seven variants represent 9% of the mutant alleles examined, and in the rest of the chromosomes the mutation responsible for the enzyme deficiency remains to be defined. Several of the variants observed in Mexico are common in Africa, South Europe, and Southeast Asia. The prevalence for the variant G-6-PD A376G was 1.64%. From 256 possible haplotypes only 14 were observed and haplotype analysis suggests that some of the G-6-PD variants probably were imported to Mexico by population flow from South Europe, Africa, and Southeast Asia. This work (i) identified the G-6-PD variants prevalent in Mexico, (ii) defines their geographical distribution, (iii) contributes to the knowledge of the genetic structure of the Mexican population, and (iv) will facilitate the molecular analysis of the G-6-PD gene in enzyme-deficient Mexican individuals. " 2002 Elsevier Science (USA).
URI: http://hdl.handle.net/20.500.12104/42920
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036430184&partnerID=40&md5=63d3a1614844c96f030f0dd147148647
Appears in Collections:Producción científica UdeG

Files in This Item:
There are no files associated with this item.


Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.