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Title: Modeling and simulating the nerve axon as a thin-film microstrip
Author: Soria-Fregozo, C.
Flores-Soto, M.E.
Perez-Vega, M.I.
Feria-Velasco, A.
Issue Date: 2013
Abstract: Introduction: Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout several brain regions. Formation of the ?4?2 and ?7 subtypes in particular is involved in the organisation of different types of memory. Furthermore, due to their location, these receptors can control the release of various types of neurotransmitters and contribute to synaptic plasticity. Methods: Rats were divided into three groups, an experimental group (E), a sham-operated group, (S) and an intact group (T). In group E, stereotactic guidance was used to induce a chemical lesion with 1 ?/?L of 5,7-dihydroxytryptamine (5,7-DHT) in the anteroventral part of the dorsal raphe nucleus (DRN). In the sham-operated group (S), animals underwent surgery including delivery of the same excipient solution to the same site. The intact group (T) received no treatment whatsoever. Twenty days after surgery, animals in all groups were euthanised by decapitation to evaluate the expression of ?4 and ?7 nAChRs by means of molecular biology techniques. Results: 5-HT denervation of the rat PFC differentially modified the expression of ?4 and ?7 receptors: while ?4 receptor expression increased, ?7 expression decreased. Conclusion: Expression differences observed between the two subtypes may be due to their separate locations. The ?4 subtype is found in postsynaptic locations and may be related to adaptive changes in postsynaptic cells, while the location of ?7 is presynaptic. This explains why the lesion and the elimination of 5-HT fibres in the CPF would cause a decrease in ?7 expression. " 2012 Sociedad Española de Neurología.",,,,,,"10.1016/j.nrl.2012.04.002",,,"","",,,,,,"4",,"Neurologia",,"212
WOS",,,,"Index Medicus;5,7-Dihydroxytryptamine/to [Toxicity];Animals;Denervation;Female;Memory/ph [Physiology];Neuronal Plasticity/de [Drug Effects];Polymerase Chain Reaction;Prefrontal Cortex/de [Drug Effects];Prefrontal Cortex/ph [Physiology];RNA/bi [Biosynthesis];RNA/ge [Genetics];Rats;Rats, Sprague-Dawley;Receptors, Nicotinic/bi [Biosynthesis];Receptors, Nicotinic/de [Drug Effects];Serotonergic Neurons/de [Drug Effects];Serotonergic Neurons/ph [Physiology];Serotonin Agents/to [Toxicity];alpha7 Nicotinic Acetylcholine Receptor/bi [Biosynthesis];alpha7 Nicotinic Acetylcholine Receptor/de [Drug Effects]",,"?4 subtype; ?7subtype; 5, 7-DHT; Acetylcholine; Acetylcholine receptor; Prefrontal cortex",,,,,,"5-HT denervation of the adult rat prefrontal cortex induces changes in the expression of ?4 and ?7 nicotinic acetylcholine receptor subtypes [La denervación 5-HT rgica córtico-frontal induce cambios en la expresión de las subunidades ?4 y ?7 de los receptores de acetilcolina tipo nicotúnico en la corteza prefrontal de la rata adulta]",,"Article" "40632","123456789/35008",,"[Büell, Julia Estela] Universidade Federal de Santa Catarina, Brazil; [Lopes, Soraia Geraldo Rozza] Universidade Federal de Santa Catarina, Brazil; [Zillmer, Juliana Graciela Vestana] Universidade Federal de Santa Catarina, Brazil; [Souza, Sabrina da Silva de] Universidade Federal de Santa Catarina, Brazil; [Silva, Denise Guerreiro Vieira da] Universidade Federal de Santa Catarina, Brazil; [Mercado-Martinez, Francisco Javier] Universidad de Guadalajara, Mexico",,"Mercado-Martinez, Francisco Javier
Silva, Denise Guerreiro Vieira da
Souza, Sabrina da Silva de
Zillmer, Juliana Graciela Vestana
Lopes, Soraia Geraldo Rozza
Büell, Julia Estela",,"2015",,,,,,,,"10.1590/S0103-73312015000100005",,"0103-7331","",,,"Portuguese",,"IMS-UERJ",,"1",,"Physis: Revista de Saúde Coletiva",,"59
74",,"25",,"ScIELO",,,,,,,,,,,"Living with renal insufficiency: obstacles to hemodialysis treatment from the perspective of sick people and their families","Vivendo com insuficiéncia renal: obstáculos na terapia da hemodiálise na perspectiva das pessoas doentes e suas familias",,"research-article" "44660","123456789/35008",,"Jiménez, A.D., Departamento de Electrónica, CUCEI, Universidad de Guadalajara, Av. Revolución No. 1500, Guadalajara, Jalisco, 44430, Mexico; Gómez, R.M., Departamento de Ciencias Computacionales e Ingenierías, CUVALLES, Universidad de Guadalajara, Av. Revolución No. 1500, Guadalajara, Jalisco, 44430, Mexico; Jiménez, J.M.D., Departamento de Neurociencias, CUCS, Universidad de Guadalajara, Av. Revolución No. 1500, Guadalajara, Jalisco, 44430, Mexico; Jiménez, S.H.D., Departamento de Neurociencias, CUCS, Universidad de Guadalajara, Av. Revolución No. 1500, Guadalajara, Jalisco, 44430, Mexico",,"Jimenez, A.D.
Gomez, R.M.
Jimenez, J.M.D.
Jimenez, S.H.D.",,"2012",,"Since Hodgkin and Huxley described the nerve axon as a cable (H-H model), many efforts have been made to find more approximated transmission line models representing the nerve axon. This paper describes a simple model that represents the nerve axon in two parts: the internodal space as a lossy thin-film microstrip line and the node of Ranvier as an active complex load. The complex load terminating the transmission line is given by the variable impedance of a tunnel diode. First, the internodal space is circuitally analyzed and electromagnetically simulated as a lossy thin-film microstrip line terminated on a complex fixed load. The transmission line circuit theory, the two-port network analysis, and a two-dimensional finite difference time domain method are used for such a task by forcing a strip subatomic metallization. Then, the transfer function of the internodal space, cascaded with the node of Ranvier, is equated to the transfer function of a transmission line section that includes a tunnel diode. This procedure is carried out in order to obtain the diode's variable impedance. The diode was introduced by Nagumo, Arimoto, and Yoshizawa for simulating the nerve axon as an active transmission line. The active transmission line is represented by the FitzHugh simplified H-H model known as the Bonhoeffer-van der Pol model. Copyright " Cambridge University Press and the European Microwave Association 2012.
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