Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/38886
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dc.contributor.authorZambrano-Velarde, M.A.
dc.contributor.authorde la O-Pena, D.
dc.contributor.authorChavez-Pena, Q.
dc.contributor.authorBedolla-Barajas, M.
dc.date.accessioned2015-09-15T17:08:53Z-
dc.date.available2015-09-15T17:08:53Z-
dc.date.issued2012
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84866793677&partnerID=40&md5=27c34a8ba5b549301accdee94a2272cd
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=22882991
dc.identifier.urihttp://hdl.handle.net/20.500.12104/38886-
dc.description.abstractimmune thrombocytopenic purpura is characterized by bleeding disorders associated with decreased platelet count secondary to antiplatelet autoantibodies. The aim of this study was to evaluate the utility of rituximab in the management of refractory immune thrombocytopenic purpura. four women with immune thrombocytopenic purpura unresponsiveness to standard therapy were evaluated in relation to clinical response and total platelets counts at different time intervals after rituximab administration. All four patients developed petechiae; two of them associated with ecchymosis, one with hematemesis and one more with transvaginal bleeding. The mean baseline platelet count was 5350/?L; in the 60th day after the first dose of rituximab the average was 175 250/?L. Complete remission was considered in three patients. rituximab is a therapeutic option for refractory inmune thrombocytopenic purpura. Nevertheless, more studies are needed to evaluate its efficacy and safety.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyMEDLINE
dc.title[Use of rituximab in resistant thrombocytopenic purpura]. [Rituximab en p�rpura trombocitop�nica inmune refractaria.]
dc.typeArticle
dc.relation.ispartofjournalRevista m�dica del Instituto Mexicano del Seguro Social
dc.relation.ispartofvolume50
dc.relation.ispartofissue2
dc.relation.ispartofpage203
dc.relation.ispartofpage208
dc.subject.keywordIndex Medicus;Adult;Algorithms;Antibodies, Monoclonal, Murine-Derived/tu [Therapeutic Use];Humans;Immunologic Factors/tu [Therapeutic Use];Middle Aged;Purpura, Thrombocytopenic, Idiopathic/dt [Drug Therapy];Young Adult
dc.contributor.affiliationZambrano-Velarde, M.A., Servicio de Hematolog�a, Divisi�n de Medicina Interna, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Universidad de Guadalajara, Guadalajara, Jalisco, M�xico.; de la O-Pe�a, D.; Ch�vez-Pe�a, Q.; Bedolla-Barajas, M.
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