Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/71230
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dc.contributor.authorTorres-Carrillo, N.M.
dc.contributor.authorTorres-Carrillo, N.
dc.contributor.authorVazquez-Del Mercado, M.
dc.contributor.authorDelgado-Rizo, V.
dc.contributor.authorOregon-Romero, E.
dc.contributor.authorParra-Rojas, I.
dc.contributor.authorMunoz-Valle, J.F.
dc.date.accessioned2015-11-19T18:57:48Z-
dc.date.available2015-11-19T18:57:48Z-
dc.date.issued2008
dc.identifier.urihttp://hdl.handle.net/20.500.12104/71230-
dc.description.abstractWe assessed whether the -844 G/A polymorphism and mRNA expression of plasminogen activator inhibitor 1 (PAI-1) gene are associated with rheumatoid arthritis (RA). Demographic data, hematological, biochemical parameters, disease activity-disability indexes, -844 G/A genotypes and mRNA expression levels of the PAI-1 gene were determined in 50 RA patients and 50 healthy subjects (HS). Non-significant differences in genotype and allele frequencies related to -844 G/A polymorphism in RA versus HS, were found. High mRNA expression of the PAI-1 gene, was demonstrated in RA versus HS (P < 0.05). In addition, A/A genotype carriers showed increase of PAI-1 mRNA expression (3.1-fold) respect to G/G and G/A genotypes in RA patients (P < 0.05). Our finding suggest an association of A/A -844 PAI-1 genotype with high PAI-1 mRNA expression in RA patients. © 2007 Springer-Verlag.
dc.titleThe -844 G/A PAI-1 polymorphism is associated with mRNA expression in rheumatoid arthritis
dc.typeArticle
dc.identifier.doi10.1007/s00296-007-0453-z
dc.relation.ispartofjournalRheumatology International
dc.relation.ispartofvolume28
dc.relation.ispartofissue4
dc.relation.ispartofpage355
dc.relation.ispartofpage360
dc.subject.keywordPlasminogen activator inhibitor-1; Polymorphism; Real-time PCR; Rheumatoid arthritis
dc.contributor.affiliationTorres-Carrillo, N.M., Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Departamento de Biología Molecular Y Genómica, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, Guadalajara, Jalisco 44340, Mexico; Torres-Carrillo, N., Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Departamento de Biología Molecular Y Genómica, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, Guadalajara, Jalisco 44340, Mexico; Vázquez-Del Mercado, M., Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Departamento de Biología Molecular Y Genómica, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, Guadalajara, Jalisco 44340, Mexico; Delgado-Rizo, V., Laboratorio de Inmunología, Departamento de Fisiología, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, Guadalajara, Jalisco 44340, Mexico; Oregón-Romero, E., Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Departamento de Biología Molecular Y Genómica, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, Guadalajara, Jalisco 44340, Mexico; Parra-Rojas, I., Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Ciudad Universitaria, Av. Lázaro Cárdenas S/N, Chilpancingo, Guerrero, Mexico; Muñoz-Valle, J.F., Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Departamento de Biología Molecular Y Genómica, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, Guadalajara, Jalisco 44340, Mexico
dc.subject.headingIndex Medicus;Adult;Aged;Arthritis, Rheumatoid/bl [Blood];Arthritis, Rheumatoid/ge [Genetics];Biological Markers/bl [Blood];Case-Control Studies;Female;Gene Frequency;Genetic Predisposition to Disease;Humans;Male;Middle Aged;Phenotype;Plasminogen Activator Inhibitor 1/ge [Genetics];Polymerase Chain Reaction;Polymorphism, Genetic;RNA, Messenger/bl [Blood];Risk Factors;Up-Regulation
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dc.relation.isReferencedByhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=17899094
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-38049065428&partnerID=40&md5=97a15478100169da337eee9a7d86a49b
dc.identifier.urlMEDLINE
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