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Title: Stage determination of breast cancer biopsy using raman spectroscopy and multivariate analysis
Author: Gonzalez-Solis, J.L.
Aguinaga-Serrano, B.I.
Martinez-Espinosa, J.C.
Oceguera-Villanueva, A.
Issue Date: 2011
Abstract: The use of Raman spectroscopy to analyze biopsy biochemistry and hence distinguish between the breast cancer stages was investigated. The biopsy samples were obtained from 13 patients who were clinically diagnosed with breast cancer. A preliminary diagnosis of some breast cancer patient was realized by pathologist of the Cancer Institute. The biopsies were put under the microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with a NIR 830 nm laser. It is shown that the breast cancer stages of biopsies can be discriminated when the Principal Components Analysis (PCA) is applied to their Raman spectra. Ratios of some band intensities were analyzed and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be an excellent technique for stage determination of breast cancer. © 2011 American Institute of Physics.
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