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Title: Short report: Neonatal screening pilot study of Toxoplasma gondii congenital infection in Mexico
Author: Vela-Amieva, M.
Canedo-Solares, I.
Gutierrez-Castrellon, P.
Perez-Andrade, M.
Gonzalez-Contreras, C.
Ortiz-Cortes, J.
Ortega-Velazquez, V.
Galvan-Ramirez, M.D.L.L.
Ruiz-Garcia, M.
Saltigeral-Simentel, P.
Ordaz-Favila, J.C.
Sanchez, C.
Correa, D.
Issue Date: 2005
Abstract: Congenital toxoplasmosis is an obstetric problem in Mexico, but its actual frequency is unknown. Using a network for screening of non-infectious disorders, we performed a pilot study to determine the frequency of IgM antibodies to Toxoplasma gondii in 1,003 infants (53.1% male, mean ± SD age = 18.3 ± 13.0 days, birth weight = 3.116 ± 0.453 kg) in Mexico City from March to April 2003. Blood samples embedded in filter paper were assayed for IgM antibodies using a capture enzyme-linked immunosorbent assay and results were confirmed by Western blot. Two asymptomatic newborns, one of them premature, had IgM and IgG antibodies in a serum sample taken from both the infant and the mother and were clinically followed. Our data suggest a frequency of approximately two cases of congenital T. gondii infection per 1,000 newborns in Mexico City. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene.
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