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Title: Detection of leukemia with blood samples using raman spectroscopy and multivariate analysis
Author: Martinez-Espinosa, J.C.
Gonzalez-Solis, J.L.
Miranda-Beltran, M.L.
Soria-Fregoso, C.
Medina-Valtierra, J.
Frausto-Reyes, C.
Issue Date: 2009
Abstract: The use of Raman spectroscopy to analyze blood biochemistry and hence distinguish between normal and abnormal blood was investigated. Blood samples were obtained from 6 patients who were clinically diagnosed with leukemia and 6 healthy volunteers. The imprint was put under the microscope and several points were chosen for Raman measurement. All the spectra were collected by a confocal Raman micro-spectroscopy (Renishaw) with a NIR 830 nm laser. It is shown that the serum samples from patients with leukemia and from the control group can be discriminated when the multivariate statistical methods of principal component analysis (PCA) and linear discriminated analysis (LDA) are applied to their Raman spectra. The ratios of some band intensities were analyzed and some band ratios were significant and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman Spectroscopy could be a new technique to study the degree of damage to the bone marrow using just blood samples instead of biopsies, treatment very painful for patients. © 2009 American Institute of Physics.
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