Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/67836
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dc.contributor.authorVelasco-Ramirez, S.F.
dc.contributor.authorRosales-Rivera, L.Y.
dc.contributor.authorRamirez-Anguiano, A.C.
dc.contributor.authorBitzer-Quintero, O.K.
dc.date.accessioned2015-11-19T18:52:31Z-
dc.date.available2015-11-19T18:52:31Z-
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/20.500.12104/67836-
dc.description.abstractIntroduction. The immune system and the peripheral and central nervous system are in constant communication by means of messengers and signalling molecules released, such as cytokines, neuropeptides, neurohormones and neuro-transmitters, among others. Seizures are defined as the transitory appearance of signs and symptoms that trigger an abnormally excessive neuronal activity in the brain. Following seizures the generation of a neuroinflammatory process has been observed to occur, with the consequent release of proinflammatory cytokines and inflammation-mediating molecules, which make the patient more prone to epilepsy. Aim. To offer evidence suggesting and supporting the role of cytokines in the appearance of seizures and in epilepsy, since these molecules have proven to have dual properties. Development. The central nervous system, by means of the blood-brain barrier, restricts the flow of activated cells and inflammation mediators released from the peripheral system towards the brain parenchyma. Moreover, there is also another series of mechanisms that contributes to the 'selective and modified' immunity of the central nervous system. The purpose of all this series of events is to limit the responses of the immune system at central level, although it has been shown that in the central nervous system they are permanently under the control and regulation of the immune system. Conclusions. Cytokines in epilepsy play a dual role with pro- and anti-convulsive properties. Seizures do not induce the expression of cytokines only inside the brain, but also peripherally. © 2013 Revista de Neurología.
dc.titleCytokines and the nervous system: The relationship between seizures and epilepsy [Citocinas y sistema nervioso: Relación con crisis convulsivas y epilepsia]
dc.typeReview
dc.relation.ispartofjournalRevista de Neurologia
dc.relation.ispartofvolume57
dc.relation.ispartofissue4
dc.relation.ispartofpage171
dc.relation.ispartofpage177
dc.subject.keywordCentral nervous system; Cytokines; Epilepsy; Inflammation; Neuroimmunology; Seizures
dc.contributor.affiliationVelasco-Ramírez, S.F., Laboratorio de Neuroinmunomodulación;, División de Neurociencias, Centro de Investigación Biomédica de Occidente, CIBO; IMSS, Mexico; Rosales-Rivera, L.Y., Laboratorio de Neuroinmunomodulación;, División de Neurociencias, Centro de Investigación Biomédica de Occidente, CIBO; IMSS, Mexico; Ramírez-Anguiano, A.C., Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, CUCEI, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Bitzer-Quintero, O.K., Laboratorio de Neuroinmunomodulación;, División de Neurociencias, Centro de Investigación Biomédica de Occidente, CIBO; IMSS, Mexico
dc.relation.isReferencedByScopus
dc.relation.isReferencedByWOS
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84881643690&partnerID=40&md5=1618aba881b6f485029d153140cce75f
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