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Title: L-5178-Y lymphoma associated immunosuppression in Balb/c mice
Author: Daneri-Navarro, Adrián.
Del Toro-Arreola, A.
Garcia-Velazco, J.C.
Del Toro-Arreola, S.
Orbach-Arbouys, S.
Bravo-Cuellar, A.
Issue Date: 1995
Abstract: Lymphoma L-5178-Y bearing Balb/c mice were unable to mount a delayed-type hypersensitivity reaction to dinitrofluorobenzene (DNFB). A suppressor factor present in the ascitis of these mice inhibited the response if given during DNFB sensitization, but not during challenge. The factor was not present in lymphoma-bearing Balb/c nu/nu mice. It appeared to be a 35-66 kDa protein. Non-specific esterase staining indicated that the spleens of tumor-bearing and ascitis-injected mice contained a large excess of macrophages. Our observation that the suppressor factor prevented the very start of the immune response may indicate why immunostimulation is difficult to obtain in cancer bearing hosts. © 1995 Elsevier, Paris.
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