Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/65455
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dc.contributor.authorOrtiz, G.G.
dc.contributor.authorPacheco-Moises, F.P.
dc.contributor.authorBitzer-Quintero, O.K.
dc.contributor.authorRamirez-Anguiano, A.C.
dc.contributor.authorFlores-Alvarado, L.J.
dc.contributor.authorRamirez-Ramirez, V.
dc.contributor.authorMacias-Islas, M.A.
dc.contributor.authorTorres-Sanchez, E.D.
dc.date.accessioned2015-11-19T18:50:23Z-
dc.date.available2015-11-19T18:50:23Z-
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/20.500.12104/65455-
dc.description.abstractMultiple sclerosis (MS) exhibits many of the hallmarks of an inflammatory autoimmune disorder including breakdown of the blood-brain barrier (BBB), the recruitment of lymphocytes, microglia, and macrophages to lesion sites, the presence of multiple lesions, generally being more pronounced in the brain stem and spinal cord, the predominantly perivascular location of lesions, the temporal maturation of lesions from inflammation through demyelination, to gliosis and partial remyelination, and the presence of immunoglobulin in the central nervous system and cerebrospinal fluid. Lymphocytes activated in the periphery infiltrate the central nervous system to trigger a local immune response that ultimately damages myelin and axons. Pro-inflammatory cytokines amplify the inflammatory cascade by compromising the BBB, recruiting immune cells from the periphery, and activating resident microglia. inflammation-associated oxidative burst in activated microglia and macrophages plays an important role in the demyelination and free radical-mediated tissue injury in the pathogenesis of MS. The inflammatory environment in demyelinating lesions leads to the generation of oxygen- and nitrogen-free radicals as well as proinflammatory cytokines which contribute to the development and progression of the disease. Inflammation can lead to oxidative stress and vice versa. Thus, oxidative stress and inflammation are involved in a self-perpetuating cycle. © 2013 Genaro G. Ortiz et al.
dc.titleImmunology and oxidative stress in multiple sclerosis: Clinical and basic approach
dc.typeReview
dc.identifier.doi10.1155/2013/708659
dc.relation.ispartofjournalClinical and Developmental Immunology
dc.relation.ispartofvolume2013
dc.contributor.affiliationOrtiz, G.G., Laboratorio de Mitocondria-Estrés Oxidativo y Patología, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada 800, CP 44340 Guadalajara, Jalisco, Mexico; Pacheco-Moisés, F.P., Departamento de Química, Centro Universitario de Ciencias de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Marcelino García Barragán 1421, CP 44430 Guadalajara, Jalisco, Mexico; Bitzer-Quintero, O.K., Laboratorio de Neuroinmunomodulación, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada 800, CP 44340 Guadalajara, Jalisco, Mexico; Ramírez-Anguiano, A.C., Departamento de Química, Centro Universitario de Ciencias de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Marcelino García Barragán 1421, CP 44430 Guadalajara, Jalisco, Mexico; Flores-Alvarado, L.J., Departamento de Bioquímica, Centro Universitario de Ciencias de Ciencias Exactas de la Salud, Universidad de Guadalajara, Sierra Mojada 950, CP 44350 Guadalajara, Jalisco, Mexico; Ramírez-Ramírez, V., Laboratorio de Mitocondria-Estrés Oxidativo y Patología, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada 800, CP 44340 Guadalajara, Jalisco, Mexico; Macias-Islas, M.A., Departamento de Neurología, Unidad Médica de Alta Especialidad, Instituto Mexicano Del Seguro Social, Belisario Dominguez 1000, CP 44340 Guadalajara, Jalisco, Mexico; Torres-Sánchez, E.D., Laboratorio de Mitocondria-Estrés Oxidativo y Patología, División de Neurociencias, Instituto Mexicano Del Seguro Social, Sierra Mojada 800, CP 44340 Guadalajara, Jalisco, Mexico
dc.relation.isReferencedByScopus
dc.relation.isReferencedByWOS
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84885601121&partnerID=40&md5=dcb5efd2e9a67811eae1f5fdee432f54
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