Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/64369
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHernandez-Ojeda, J.
dc.contributor.authorRoman-Pintos, L.M.
dc.contributor.authorRodriguez-Carrizalez, A.D.
dc.contributor.authorTroyo-Sanroman, R.
dc.contributor.authorCardona-Munoz, E.G.
dc.contributor.authorAlatorre-Carranza, A.-C.
dc.contributor.authorMiranda-Diaz, A.G.
dc.date.accessioned2015-11-19T18:49:20Z-
dc.date.available2015-11-19T18:49:20Z-
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/20.500.12104/64369-
dc.description.abstractBackground: Diabetic neuropathy affects 50%–66% of patients with diabetes mellitus. Oxidative stress generates nerve dysfunction by causing segmental demyelinization and axonal degeneration. Antioxidants are considered to be the only etiologic management for diabetic polyneuropathy, and statins such as rosuvastatin increase nitric oxide bioavailability and reduce lipid peroxidation. The aim of this study was to evaluate the antioxidant effect of rosuvastatin in diabetic polyneuropathy.Methods: We conducted a randomized, double-blind, placebo-controlled Phase IIa clinical trial in patients with type 2 diabetes and diabetic polyneuropathy (DPN) stage $1b. We allo­cated subjects to two parallel groups (1:1) that received rosuvastatin 20 mg or placebo for 12 weeks. Primary outcomes were neuropathic symptom score, disability score, and nerve conduction studies, and secondary outcomes were glycemic control, lipid and hepatic profile, lipid peroxidation, and nerve growth factor beta (NGF-β) levels.Results: Both groups were of similar age and duration since diagnosis of diabetes and DPN. We observed improvement of DPN in the rosuvastatin group from stage 2a (88.2%) to stage 1b (41.2%), improvement of neuropathic symptom score from 4.5±2 to 2.4±1.8, and significant (P=0.001) reductions of peroneal nerve conduction velocity (from 40.8±2.2 to 42.1±1.6 seconds) and lipid peroxidation (from 25.4±2 to 12.2±4.0 nmol/mL), with no significant change in gly­cemic control or β-NGF.Conclusion: The severity, symptoms, and nerve conduction parameters of DPN improved after 12 weeks of treatment with rosuvastatin. These beneficial effects appear to be attributable to reductions in lipid peroxidation and oxidative stress. © 2014 Hernández-Ojeda et al.
dc.titleEffect of rosuvastatin on diabetic polyneuropathy: A randomized, double-blind, placebo-controlled Phase IIa study
dc.typeArticle
dc.identifier.doi10.2147/DMSO.S65500
dc.relation.ispartofjournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
dc.relation.ispartofvolume7
dc.relation.ispartofpage401
dc.relation.ispartofpage407
dc.subject.keywordDiabetic polyneuropathy; Nerve conduction; Nerve growth factor beta; Oxidative stress; Rosuvastatin
dc.contributor.affiliationHernández-Ojeda, J., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraJalisco, Mexico; Román-Pintos, L.M., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraJalisco, Mexico; Rodríguez-Carrízalez, A.D., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraJalisco, Mexico; Troyo-Sanromán, R., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraJalisco, Mexico; Cardona-Muñoz, E.G., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraJalisco, Mexico; Alatorre-Carranza, A.-C., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraJalisco, Mexico; Miranda-Díaz, A.G., Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de GuadalajaraJalisco, Mexico
dc.relation.isReferencedByScopus
dc.relation.isReferencedByMEDLINE
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84907879862&partnerID=40&md5=42cc87cac37fffb3d27fb63e2b00ca86
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25214797
Appears in Collections:Producción científica UdeG (prueba)

Files in This Item:
There are no files associated with this item.


Items in RIUdeG are protected by copyright, with all rights reserved, unless otherwise indicated.