Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/63142
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dc.contributor.authorCasas-Castaneda, M.
dc.contributor.authorHernandez-Lugo, I.
dc.contributor.authorTorres, O.
dc.contributor.authorBarajas, H.
dc.contributor.authorCibrian, S.
dc.contributor.authorZamudio, G.
dc.contributor.authorVillalobos-Arambula, A.R.
dc.contributor.authorHermosillo-Banuelos, R.M.
dc.contributor.authorPerea, F.J.
dc.contributor.authorIbarra, B.
dc.date.accessioned2015-11-18T23:43:37Z-
dc.date.available2015-11-18T23:43:37Z-
dc.date.issued1998
dc.identifier.urihttp://hdl.handle.net/20.500.12104/63142-
dc.description.abstractObjective. To identify by molecular biology the alleles of α-Thal in selected hospital populations. Methods. Eighteen propositi with hematological and biochemical data suggestive of α-thalassemia, selected from 356 patients of four hospitals in two cities with probable hemoglobinopathy were investigated for six common α-Thal alleles. Molecular studies were done by PCR and digestion with specific restriction enzymes. Results. The α 3.7 allele was identified in two cases and the family study revealed the same allele in the mother; HbS heterozigocity was also detected in one of them. An analysis with Apa I demonstrated a class I deletion in both patients. The present study showed 2/356 (0.6%) of α 3.71 carriers which is a low frequency as compared with other countries. As no other common α-thalassemia alleles were found, we suspect that α-Thal in Mexico is as heterogeneous at a molecular level as β-Thal.
dc.titleAlpha-thalassemia in a selected population of Mexico
dc.typeArticle
dc.relation.ispartofjournalRevista de Investigacion Clinica
dc.relation.ispartofvolume50
dc.relation.ispartofissue5
dc.relation.ispartofpage395
dc.relation.ispartofpage398
dc.subject.keywordAlpha-thalassemia; Hemoglobinopathies; Hemolytic anemias; Mexico; Thalassemia
dc.contributor.affiliationCasas-Castañeda, M., Divisiones de Genética, Ctro. Invest. Biomedica Occidente, Guadalajara, Jal., Mexico; Hernandez-Lugo, I., Hospital General de Zona No. 46, Guadalajara, Jal., Mexico; Torres, O., Banco de Sangre Central, CMNO, IMSS, Guadalajara, Jal., Mexico; Barajas, H., Hosp. de Gineco Pediat. No. 48, CMN, IMSS, León, Gto., Mexico; Cibrian, S., Hosp. de Gineco Pediat. No. 48, CMN, IMSS, León, Gto., Mexico; Zamudio, G., Divisiones de Genética, Ctro. Invest. Biomedica Occidente, Guadalajara, Jal., Mexico; Villalobos-Arambula, A.R., Depto. de Biol. Celular y Molecular, CUCBA, Universidad de Guadalajara, Mexico; Hermosillo-Bañuelos, R.M., Divisiones de Genética, Ctro. Invest. Biomedica Occidente, Guadalajara, Jal., Mexico; Perea, F.J., Divisiones de Medicina Molecular, Ctro. Invest. Biomedica Occidente, Guadalajara, Jal., Mexico; Ibarra, B., Divisiones de Genética, Ctro. Invest. Biomedica Occidente, Guadalajara, Jal., Mexico, División de Genética, Ctro. Invest. Biomedica O., IMSS, Apartado 1-3838, Guadalajara, Jal., Mexico
dc.relation.isReferencedByScopus
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-17644428484&partnerID=40&md5=79616c1a231d61b2cdf7915663aafdc0
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