Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/45497
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dc.contributor.authorOregon-Romero, E.
dc.contributor.authorVazquez-Del Mercado, M.
dc.contributor.authorNavarro-Hernandez, R.E.
dc.contributor.authorTorres-Carrillo, N.
dc.contributor.authorMartinez-Bonilla, G.
dc.contributor.authorEstrada-Garcia, I.
dc.contributor.authorRangel-Villalobos, H.
dc.contributor.authorMunoz-Valle, J.F.
dc.date.accessioned2015-09-15T19:14:32Z-
dc.date.available2015-09-15T19:14:32Z-
dc.date.issued2006
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-33750450860&partnerID=40&md5=898c75b8c265a10fbbeb3811c8b70c2c
dc.identifier.urihttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16871413
dc.identifier.urihttp://hdl.handle.net/20.500.12104/45497-
dc.description.abstractWe investigate the clinical association of tumor necrosis factor receptor 2 (TNFR2) M196R polymorphism with rheumatoid arthritis (RA) and knee osteoarthritis (OA). Acute phase reactants, lipid profile, sTNFR2 levels, disease activity-disability indexes, and TNFR2 M196R polymorphism were analyzed in 50 RA, 50 knee OA patients, and 120 healthy subjects (HS). The M/M genotype frequency was 0.74 (RA), 0.80 (OA), and 0.64 (HS). The M/R genotype frequency was RA (0.26), OA (0.20), and HS (0.29). The R/R genotype was observed only in HS (0.07). The M allele was associated with OA (P = 0.0137, OR = 2.43). Total cholesterol, triglyceride levels, apolipoprotein A-I and B showed significant differences (P < 0.05). The highest sTNFR2 levels were observed in RA and OA (P = 0.001), however M/M and M/R carriers do not correlate with sTNFR2 production. Our findings suggest an association of the M allele with knee OA. In addition, high sTNFR2 levels in RA and OA were found. � 2006 Springer-Verlag.
dc.relation.isreferencedbyScopus
dc.relation.isreferencedbyMEDLINE
dc.relation.isreferencedbyWOS
dc.titleTumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: Relationship with sTNFR2 levels and clinical features
dc.typeArticle
dc.identifier.doi10.1007/s00296-006-0159-7
dc.relation.ispartofjournalRheumatology International
dc.relation.ispartofvolume27
dc.relation.ispartofissue1
dc.relation.ispartofpage53
dc.relation.ispartofpage59
dc.subject.keywordOsteoarthritis; Polymorphism; Rheumatoid arthritis; Tumor necrosis factor receptor 2
dc.contributor.affiliationOreg�n-Romero, E., Ciencias Biom�dicas, Orientaci�n en Inmunolog�a, Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Universidad de Guadalajara, S. Mojada No. 950, Col. Independ., 44340 Guadalajara, Jalisco, Mexico; V�zquez-Del Mercado, M., Ciencias Biom�dicas, Orientaci�n en Inmunolog�a, Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Universidad de Guadalajara, S. Mojada No. 950, Col. Independ., 44340 Guadalajara, Jalisco, Mexico; Navarro-Hern�ndez, R.E., Ciencias Biom�dicas, Orientaci�n en Inmunolog�a, Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Universidad de Guadalajara, S. Mojada No. 950, Col. Independ., 44340 Guadalajara, Jalisco, Mexico; Torres-Carrillo, N., Ciencias Biom�dicas, Orientaci�n en Inmunolog�a, Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Universidad de Guadalajara, S. Mojada No. 950, Col. Independ., 44340 Guadalajara, Jalisco, Mexico; Mart�nez-Bonilla, G., Servicio de Reumatolog�a, Hospital Civil Fray Antonio Alcalde, Hospital No. 278, Col. El Retiro, 44100 Guadalajara, Jalisco, Mexico; Estrada-Garc�a, I., Departamento de Inmunolog�a, Escuela Nacional de Ciencias Biol�gicas Instituto Polit�cnico Nacional, C. y P. de Ayala s/n, Col. S. Tomas, 11340 Mexico D.F., Mexico; Rangel-Villalobos, H., Laboratorio de Gen�tica Molecular, Centro Universitario de la Ci�nega, Universidad de Guadalajara, Km 3.3 carretera Ocotlan-Tototlan, Ocotl�n, Jalisco, Mexico; Mu�oz-Valle, J.F., Ciencias Biom�dicas, Orientaci�n en Inmunolog�a, Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Universidad de Guadalajara, S. Mojada No. 950, Col. Independ., 44340 Guadalajara, Jalisco, Mexico, Instituto de Investigacion en Reumatologia Y del Sistema Musculo Esqueletico, Centro Universitario de Ciencias de la Salud, Sierra Mojada Street No. 950, 44281 Guadalajara, Jalisco, Mexico
dc.subject.headingIndex Medicus;Adult;Aged;Aged, 80 and over;Apolipoprotein A-I/bl [Blood];Apolipoproteins B/bl [Blood];Arthritis, Rheumatoid/bl [Blood];Arthritis, Rheumatoid/ge [Genetics];Case-Control Studies;Cholesterol/bl [Blood];Disability Evaluation;Genotype;Humans;Mexico;Middle Aged;Osteoarthritis, Knee/bl [Blood];Osteoarthritis, Knee/ge [Genetics];Polymorphism, Genetic/ge [Genetics];Receptors, Tumor Necrosis Factor, Type II/ge [Genetics];Severity of Illness Index;Triglycerides/bl [Blood]
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