Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12104/45497
Title: Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: Relationship with sTNFR2 levels and clinical features
Author: Oregon-Romero, E.
Vazquez-Del Mercado, M.
Navarro-Hernandez, R.E.
Torres-Carrillo, N.
Martinez-Bonilla, G.
Estrada-Garcia, I.
Rangel-Villalobos, H.
Munoz-Valle, J.F.
Issue Date: 2006
Abstract: We investigate the clinical association of tumor necrosis factor receptor 2 (TNFR2) M196R polymorphism with rheumatoid arthritis (RA) and knee osteoarthritis (OA). Acute phase reactants, lipid profile, sTNFR2 levels, disease activity-disability indexes, and TNFR2 M196R polymorphism were analyzed in 50 RA, 50 knee OA patients, and 120 healthy subjects (HS). The M/M genotype frequency was 0.74 (RA), 0.80 (OA), and 0.64 (HS). The M/R genotype frequency was RA (0.26), OA (0.20), and HS (0.29). The R/R genotype was observed only in HS (0.07). The M allele was associated with OA (P = 0.0137, OR = 2.43). Total cholesterol, triglyceride levels, apolipoprotein A-I and B showed significant differences (P < 0.05). The highest sTNFR2 levels were observed in RA and OA (P = 0.001), however M/M and M/R carriers do not correlate with sTNFR2 production. Our findings suggest an association of the M allele with knee OA. In addition, high sTNFR2 levels in RA and OA were found. � 2006 Springer-Verlag.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-33750450860&partnerID=40&md5=898c75b8c265a10fbbeb3811c8b70c2c
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=16871413
http://hdl.handle.net/20.500.12104/45497
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